Document Detail

Relationship between cerebral hypoxic tissue volume and prognosis after stroke.
MedLine Citation:
PMID:  20029217     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Between 50 and 70% of stroke survivors suffer from severe disabilities such as paralysis and aphasia. Poor stroke outcome is a reflection of our incomplete understanding of the underlying mechanisms, and hence the capacity to implement appropriate treatment(s). We evaluated hypoxic tissue after stroke and patient condition severity and prognosis. METHODS: Hypoxic tissue volume was quantified within 14 days after stroke. Patients were classified as hypoxic positive or negative. Patients were evaluated at imaging and 21 days later. Prognosis was assessed at 30 and 90 days. RESULTS: Significant improvement was shown in hypoxia-positive (vs. hypoxia-negative) patients (p < 0.05). There were significant positive relationships between the volume of hypoxic tissue and the improvement in specialized test scores at 90 days (p < 0.05 for both). Presence of hypoxic tissue within 14 days after cerebral stroke was related to recovery at 3 weeks and prognosis at 90 days. CONCLUSIONS: The assessment of hypoxic tissue volume after stroke may be useful in predicting patient recovery.
Yi-Dong Wang; Xiang-Pen Li; Mei Li; Sheng Liu; Xian-Ping Lu; Ying Peng; Ru-Xun Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-23
Journal Detail:
Title:  European neurology     Volume:  63     ISSN:  1421-9913     ISO Abbreviation:  Eur. Neurol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  52-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Department of Neurology, Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
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MeSH Terms
Aged, 80 and over
Brain Infarction / diagnosis*,  pathology*,  radiography
Cerebrovascular Circulation
Cerebrum / pathology*,  radiography,  radionuclide imaging
Hypoxia, Brain / pathology*,  radiography,  radionuclide imaging
Middle Aged
Multivariate Analysis
Regression Analysis
Severity of Illness Index
Stroke / diagnosis*,  pathology*,  radionuclide imaging
Time Factors
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed

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