| Relationship between CRP polymorphism and cardiovascular events in Chinese peritoneal dialysis patients. | |
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MedLine Citation:
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PMID: 22241816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: The single-nucleotide polymorphism (SNP) -717A→G substitution, rs2794521, was found in the promoter of the C-reactive protein (CRP) gene. Functional studies showed that A allele promoter has higher transcriptional activity than the G allele. This study investigated the association between this SNP and the outcome of Chinese patients undergoing peritoneal dialysis (PD). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The study included 441 new PD patients (232 men; mean age ± SD, 56.7±13.5 years). CRP genotyping was determined; patients were followed for 41.3±18.3 months for cardiovascular events. RESULTS: For the entire cohort, 5-year event-free survival rates did not differ between the AA and AG/GG groups (35.7% and 31.9%, respectively; P=0.64). However, there was significant interaction between plasma cholesterol levels and CRP genotype groups on event-free survival (P=0.04 for interaction). For patients with cholesterol levels of 200 mg/dl or greater, the 5-year event-free survival rate in the AG/GG group was significantly better than that in the AA group (54.7% versus 40.0%; P=0.04), whereas there was no difference in event-free survival between genotype groups for patients with cholesterol levels less than 200 mg/dl. CONCLUSIONS: CRP gene -717AG or GG genotypes is associated with cardiovascular benefit to Chinese PD patients with cholesterol levels of 200 mg/dl or greater. These findings suggest a complex interaction among cholesterol, CRP, and cardiovascular disease in PD patients. |
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Authors:
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Peter Yam-Kau Poon; Cheuk-Chun Szeto; Bonnie Ching-Ha Kwan; Kai-Ming Chow; Philip Kam-Tao Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-01-12 |
Journal Detail:
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Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 7 ISSN: 1555-905X ISO Abbreviation: Clin J Am Soc Nephrol Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-16 Completed Date: 2012-06-12 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 304-9 Citation Subset: IM |
Affiliation:
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Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Asian Continental Ancestry Group / genetics* C-Reactive Protein / genetics* Cardiovascular Diseases / blood, genetics*, mortality Chi-Square Distribution China / epidemiology Cholesterol / blood Disease-Free Survival Female Genotype Humans Kaplan-Meier Estimate Kidney Diseases / blood, complications, ethnology, genetics, mortality, therapy* Male Middle Aged Peritoneal Dialysis / adverse effects*, mortality Phenotype Polymorphism, Single Nucleotide* Proportional Hazards Models Risk Assessment Risk Factors Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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57-88-5/Cholesterol; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
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