| Relationship between CRP Polymorphism and Cardiovascular Events in Chinese Peritoneal Dialysis Patients. | |
| | |
MedLine Citation:
|
PMID: 22241816 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background and objectivesThe single-nucleotide polymorphism (SNP) -717A→G substitution, rs2794521, was found in the promoter of the C-reactive protein (CRP) gene. Functional studies showed that A allele promoter has higher transcriptional activity than the G allele. This study investigated the association between this SNP and the outcome of Chinese patients undergoing peritoneal dialysis (PD).Design, setting, participants, & measurementsThe study included 441 new PD patients (232 men; mean age ± SD, 56.7±13.5 years). CRP genotyping was determined; patients were followed for 41.3±18.3 months for cardiovascular events.ResultsFor the entire cohort, 5-year event-free survival rates did not differ between the AA and AG/GG groups (35.7% and 31.9%, respectively; P=0.64). However, there was significant interaction between plasma cholesterol levels and CRP genotype groups on event-free survival (P=0.04 for interaction). For patients with cholesterol levels of 200 mg/dl or greater, the 5-year event-free survival rate in the AG/GG group was significantly better than that in the AA group (54.7% versus 40.0%; P=0.04), whereas there was no difference in event-free survival between genotype groups for patients with cholesterol levels less than 200 mg/dl.Conclusions CRP gene -717AG or GG genotypes is associated with cardiovascular benefit to Chinese PD patients with cholesterol levels of 200 mg/dl or greater. These findings suggest a complex interaction among cholesterol, CRP, and cardiovascular disease in PD patients. |
| | |
Authors:
|
Peter Yam-Kau Poon; Cheuk-Chun Szeto; Bonnie Ching-Ha Kwan; Kai-Ming Chow; Philip Kam-Tao Li |
Related Documents
:
|
15603666 - Hypocalcemia complicating near-total thyroidectomy in patients with coexisting lipid ma... 6587966 - Lacrimal gland accumulation of 67ga-citrate in patients with sjögren's syndrome. 6166476 - Early kinetics of thyroid trap in normal human patients and in thyroid diseases. 9227866 - Hyperthyroidism with or without pyramidal lobe graves' disease or disseminated autonomo... 6092086 - In vivo isotope study of the thyroid with 99mtco4- in neonatal congenital hypothyroidism. 11419176 - Herpes simplex virus 1 pneumonia: conventional chest radiograph pattern. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
|
Title: Clinical journal of the American Society of Nephrology : CJASN Volume: - ISSN: 1555-905X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Electrophysiological Examination of Embodiment in Vision and Action.
Next Document: Localization of Tubular Adaptation to Renal Sodium Loss in Gitelman Syndrome.