Document Detail


Relationship between CRP polymorphism and cardiovascular events in Chinese peritoneal dialysis patients.
MedLine Citation:
PMID:  22241816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: The single-nucleotide polymorphism (SNP) -717A→G substitution, rs2794521, was found in the promoter of the C-reactive protein (CRP) gene. Functional studies showed that A allele promoter has higher transcriptional activity than the G allele. This study investigated the association between this SNP and the outcome of Chinese patients undergoing peritoneal dialysis (PD).
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The study included 441 new PD patients (232 men; mean age ± SD, 56.7±13.5 years). CRP genotyping was determined; patients were followed for 41.3±18.3 months for cardiovascular events.
RESULTS: For the entire cohort, 5-year event-free survival rates did not differ between the AA and AG/GG groups (35.7% and 31.9%, respectively; P=0.64). However, there was significant interaction between plasma cholesterol levels and CRP genotype groups on event-free survival (P=0.04 for interaction). For patients with cholesterol levels of 200 mg/dl or greater, the 5-year event-free survival rate in the AG/GG group was significantly better than that in the AA group (54.7% versus 40.0%; P=0.04), whereas there was no difference in event-free survival between genotype groups for patients with cholesterol levels less than 200 mg/dl.
CONCLUSIONS: CRP gene -717AG or GG genotypes is associated with cardiovascular benefit to Chinese PD patients with cholesterol levels of 200 mg/dl or greater. These findings suggest a complex interaction among cholesterol, CRP, and cardiovascular disease in PD patients.
Authors:
Peter Yam-Kau Poon; Cheuk-Chun Szeto; Bonnie Ching-Ha Kwan; Kai-Ming Chow; Philip Kam-Tao Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-12
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  7     ISSN:  1555-905X     ISO Abbreviation:  Clin J Am Soc Nephrol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-16     Completed Date:  2012-06-12     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  304-9     Citation Subset:  IM    
Affiliation:
Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Analysis of Variance
Asian Continental Ancestry Group / genetics*
C-Reactive Protein / genetics*
Cardiovascular Diseases / blood,  genetics*,  mortality
Chi-Square Distribution
China / epidemiology
Cholesterol / blood
Disease-Free Survival
Female
Genotype
Humans
Kaplan-Meier Estimate
Kidney Diseases / blood,  complications,  ethnology,  genetics,  mortality,  therapy*
Male
Middle Aged
Peritoneal Dialysis / adverse effects*,  mortality
Phenotype
Polymorphism, Single Nucleotide*
Proportional Hazards Models
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
57-88-5/Cholesterol; 9007-41-4/C-Reactive Protein
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