Document Detail

Relationship between bone mineral density and serum osteoprotegerin in patients with chronic heart failure.
MedLine Citation:
PMID:  22957004     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Heart failure (HF) had been reported with increased risk of hip fractures. However, the relationship between circulating biomarkers and bone mineral density (BMD) in chronic HF remained unclear.
METHODS: This is a cross-sectional study which recruited stable chronic HF from registry of the Heart Failure Center of National Taiwan University Hospital. Patients underwent dual-energy x-ray absorptiometry (DEXA) measurements at hip and lumbar spines and biochemical assessments including B-type natriuretic peptide (BNP-32), myostatin, follistatin and osteoprotegerin (OPG).
RESULTS: A total of 115 stable chronic HF individuals with left ventricular ejection fraction (EF) <45% (74% of male, mean age at 59) were recruited with 24 patients in NYHA class I, 73 patients in NYHA class II and 18 patients in NYHA class III. Results of BMD showed that Z scores of hip in NYHA III group (-0.12 ± 1.15) was significantly lower than who were NYHA II (0.58 ± 1.04). Serum OPG was significantly higher in subjects of NYHA III (9.3 ± 4.6 pmol/l) than NYHA II (7.4 ± 2.8 pmol/l) or NYHA I (6.8 ± 3.6 pmol/l) groups. There's a significant negative association between log transformed serum OPG and trochanteric BMD (R = -0.299, P = 0.001), which remained significant after multivariate analysis.
CONCLUSIONS: Our study demonstrated an inverse association between serum OPG and trochanteric BMD in patients with HF. OPG may be a predictor of BMD and an alternative to DEXA for identifying at risk HF patients for osteoporosis.
Ying-Hsien Chen; Yen-Wen Wu; Wei-Shiung Yang; Shoei-Shen Wang; Chi-Ming Lee; Nai-Kuan Chou; Ron-Bin Hsu; Yen-Hung Lin; Mao-Shin Lin; Yi-Lwun Ho; Ming-Fong Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-30
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-01-21     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e44242     Citation Subset:  IM    
National Taiwan University College of Medicine, Taipei, Taiwan.
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MeSH Terms
Absorptiometry, Photon
Biological Markers / blood
Bone Density*
Chronic Disease
Cross-Sectional Studies
Femur / physiopathology,  radiography
Heart Failure / blood*,  physiopathology,  radiography
Lumbar Vertebrae / physiopathology,  radiography
Middle Aged
Multivariate Analysis
Osteoporosis / blood*,  physiopathology,  radiography
Osteoprotegerin / blood*
Reg. No./Substance:
0/Biological Markers; 0/Osteoprotegerin; 0/TNFRSF11B protein, human

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