Document Detail

Relationship between blood levels of heavy metals and Parkinson's disease in China.
MedLine Citation:
PMID:  19893325     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Idiopathic Parkinson's disease (PD) and the Parkinsonian syndrome caused by manganese (Mn) poisoning are known to be indistinguishable in terms of symptoms. We thus suspect that many patients who have accumulated Mn in the body in daily life are diagnosed as having idiopathic PD. We examined the relationship between PD and blood levels of heavy metals, and the influence of intake from food in a general population. METHODS: The subjects comprised PD patients and sex- and age-matched controls recruited from the outpatient clinic of Xiangfan No. 1 People's Hospital in Hubei, China, between 2006 and 2008. Information was obtained on previous eating habits before diagnosis of PD and other factors. Morning blood samples were collected before breakfast and were used to measure concentrations of metals. RESULTS: The whole-blood Mn and serum iron (Fe) levels were significantly higher in PD patients than in controls. However, no differences in intake of each metal from food or experience of Mn poisoning were seen between the groups. CONCLUSIONS: In China, accumulation of Mn and Fe via unknown routes might be involved in the etiology of PD in the general population.
Tetsuhito Fukushima; Xiaodong Tan; Yunwen Luo; Hideyuki Kanda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-05
Journal Detail:
Title:  Neuroepidemiology     Volume:  34     ISSN:  1423-0208     ISO Abbreviation:  Neuroepidemiology     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8218700     Medline TA:  Neuroepidemiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  18-24     Citation Subset:  IM    
Copyright Information:
2009 S. Karger AG, Basel.
Department of Hygiene and Preventive Medicine, Fukushima Medical University School of Medicine, Fukushima City, Japan.
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MeSH Terms
China / epidemiology
Iron / administration & dosage,  blood*
Manganese / administration & dosage,  blood*
Metals, Heavy / administration & dosage,  blood
Middle Aged
Parkinson Disease / blood*,  epidemiology*
Rural Population
Socioeconomic Factors
Time Factors
Urban Population
Reg. No./Substance:
0/Metals, Heavy; 7439-89-6/Iron; 7439-96-5/Manganese

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