Document Detail

Relationship between Acute Chest Syndrome and the sympatho-vagal balance in adults with hemoglobin SS disease; a case control study.
MedLine Citation:
PMID:  22460267     Owner:  NLM     Status:  Publisher    
The present study evaluated the relationship between acute chest syndrome (ACS) and autonomic nervous system (ANS) activity in patients with hemoglobin SS disease (SCD). Nine patients had suffered ACS were matched by age and gender to patients who had not suffered ACS and ANS activity, pulmonary function and history of painful crisis were compared. Correlations between number of episodes of ACS suffered and these variables were determined. The results demonstrated that 1) patients with a history of ACS ever had lower parasympathetic nervous system (PNS) activity and lower global ANS activity than patients with no ACS ever (p < 0.05), 2) the number of ACS episodes ever negatively correlated (p < 0.05) with PNS activity and global ANS activity and 3) There were no significant associations between lung function or a history of painful crisis in these patients. In conclusion, a history of ACS was associated with ANS dysfunction in adults with SCD.
Jennifer M Knight-Madden; Philippe Connes; Andre Bowers; Danitza Nebor; Marie-Dominique Hardy-Dessources; Marc Romana; Harvey Reid; Aurélien P Pichon; Jean-Claude Barthélémy; Vanessa B Cumming; Jacques Elion; Marvin Reid
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-29
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  -     ISSN:  1875-8622     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Sickle Cell Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica, West Indies CAREST (CAribbean network of REsearchers on Sickle cell disease and Thalassemia).
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