Document Detail


Relationship between A2A adenosine receptor expression and intradialytic hypotension during hemodialysis.
MedLine Citation:
PMID:  17169272     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Intradialytic hypotension (IDH) is a common complication of hemodialysis sessions (HDSs). Adenosine may contribute to the drop in blood pressure during IDH events because it has hypotensive effects. As A(2A) adenosine receptor expression is essential for blood pressure control, we compared the expression of A(2A) receptors (Bmax, K(D), and messenger ribonucleic acid [mRNA] levels) in peripheral blood mononuclear cells from IDH and non-IDH patients and from controls. We also evaluated adenosine plasma levels (APLs). METHODS: We included 10 hemodialyzed patients with at least three IDH events per month. We also included 11 hemodialyzed patients with no history of IDH events and 10 healthy subjects as controls. RESULTS: IDH patients had higher Bmax values than non-IDH patients (mean before HDS, +86%; after HDS, +112%), whereas non-IDH patients had lower Bmax values than controls (mean -72%). K(D) values were not significantly different between patients and controls. The levels of mRNA increased significantly during HDS but without an increase in receptor expression on the cell membranes. APLs were higher in hemodialyzed patients than in controls. CONCLUSION: We found that A(2A) receptors are more expressed in IDH patients than in non-IDH patients, whereas APL was high in all patients. Both high APL and a relative increase in A(2A) receptor expression may favor IDH events.
Authors:
Philippe Giaime; Louis Carrega; Emmanuel Fenouillet; Laurence Mercier; Victoria Gerolami; Jean Ruf; Nicole Sauze; Philippe Brunet; Alain Saadjian; Yvon Berland; Bertrand Dussol; Regis Guieu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of investigative medicine : the official publication of the American Federation for Clinical Research     Volume:  54     ISSN:  1081-5589     ISO Abbreviation:  J. Investig. Med.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-15     Completed Date:  2007-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501229     Medline TA:  J Investig Med     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
Affiliation:
Service de Néphrologie et d'Hémodialyse, Hôpital de la Conception, Marseille, France.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / blood
Aged
Base Sequence
Case-Control Studies
Female
Humans
Hypotension / etiology*,  genetics,  metabolism
Male
Middle Aged
Prospective Studies
RNA, Messenger / genetics,  metabolism
Receptors, Adenosine A2 / genetics,  metabolism*
Renal Dialysis / adverse effects*
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Adenosine A2; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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