Document Detail


Relationship of arousal to circadian anticipatory behavior: ventromedial hypothalamus: one node in a hunger-arousal network.
MedLine Citation:
PMID:  19863654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanisms by which animals adapt to an ever-changing environment have long fascinated scientists. Different forces, conveying information regarding various aspects of the internal and external environment, interact with each other to modulate behavioral arousal. These forces can act in concert or, at times, in opposite directions. These signals eventually converge and are integrated to influence a common arousal pathway which, depending on all the information received from the environment, supports the activation of the most appropriate behavioral response. In this review we propose that the ventromedial hypothalamic nucleus (VMN) is part of the circuitry that controls food anticipation. It is the first nucleus activated when there is a change in the time of food availability, silencing of VMN ghrelin receptors decreases food-anticipatory activity (FAA) and, although lesions of the VMN do not abolish FAA, parts of the response are often altered. In proposing this model it is not our intention to exclude parallel, redundant and possibly interacting pathways that may ultimately communicate with, or work in concert with, the proposed network, but rather to describe the neuroanatomical requirements for this circuit and to illustrate how the VMN is strategically placed and connected to mediate this complex behavioral adaptation.
Authors:
Ana C Ribeiro; Joseph LeSauter; Christophe Dupré; Donald W Pfaff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-10-26
Journal Detail:
Title:  The European journal of neuroscience     Volume:  30     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-13     Completed Date:  2010-01-15     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1730-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arousal / physiology*
Biological Clocks / physiology
Circadian Rhythm / physiology*
Eating / physiology
Feeding Behavior / physiology*
Homeostasis
Hunger / physiology*
Motor Activity / physiology
Neural Pathways / anatomy & histology,  physiology
Ventromedial Hypothalamic Nucleus / anatomy & histology,  physiology*
Grant Support
ID/Acronym/Agency:
F32 HL086018-03/HL/NHLBI NIH HHS; HD-05751/HD/NICHD NIH HHS; HL-086018/HL/NHLBI NIH HHS; NS-37919/NS/NINDS NIH HHS; R01 HD005751/HD/NICHD NIH HHS; R01 HD005751-26/HD/NICHD NIH HHS; R01 NS037919/NS/NINDS NIH HHS; R01 NS037919-05/NS/NINDS NIH HHS; R01 NS037919-12/NS/NINDS NIH HHS; R37 HD005751/HD/NICHD NIH HHS; R37 HD005751-36S1/HD/NICHD NIH HHS
Comments/Corrections

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