Document Detail


Relationship of apolipoprotein B levels to the number of risk factors for metabolic syndrome.
MedLine Citation:
PMID:  17850735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Low-density lipoprotein cholesterol (LDL-C) is the primary target of lipid-lowering therapy. However, all lipoproteins containing apolipoprotein B (apo B) appear to be atherogenic. Preferred targets of therapy therefore may include either the cholesterol in all apo B-containing lipoproteins (non-high-density lipoprotein cholesterol [non-HDL-C]) or total apo B itself. Apo B can be measured by three methods: chemically, by nuclear magnetic resonance (NMR), and by immunoassay. This study compares the first two methods as a function of the number of metabolic risk factors in patients with metabolic syndrome. Plasma lipid, lipoprotein cholesterol, and apo B levels were measured in 274 adults with varying numbers of metabolic syndrome components. Low-density lipoprotein (LDL) particle sizes were measured by gel electrophoresis and by NMR. Total apo B was estimated chemically and by conversion of NMR lipoprotein particle number, assuming one apo B molecule per lipoprotein particle. As the number of metabolic syndrome components increased, apo B rose by both chemical and NMR methods, but by chemical methods, increases were in the triglyceride-rich fraction, whereas by NMR, they were in LDL. The correlation between total apo B measured by the two methods was only moderate (r = .73). Further, non-HDL-C was more highly correlated with total apo B measured chemically than either LDL-C or total apo B by NMR. Non-HDL-C correlates highly with total apo B in patients with metabolic syndrome and had advantages as a target of therapy over LDL-C or NMR apo B.
Authors:
Jacob J Clarenbach; Scott M Grundy; Natalia Palacio; Gloria Lena Vega
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigative medicine : the official publication of the American Federation for Clinical Research     Volume:  55     ISSN:  1081-5589     ISO Abbreviation:  J. Investig. Med.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-09-13     Completed Date:  2007-11-02     Revised Date:  2007-11-30    
Medline Journal Info:
Nlm Unique ID:  9501229     Medline TA:  J Investig Med     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  237-47     Citation Subset:  IM    
Affiliation:
Center for Human Nutrition, the Donald W Reynolds Cardiovascular Research Center of the University of Texas Southwestern Medical Center at Dallas, TX 75390-9052, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Apolipoproteins B / blood*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Female
Humans
Lipoproteins, HDL / blood
Magnetic Resonance Spectroscopy
Male
Metabolic Syndrome X / blood,  etiology*
Middle Aged
Particle Size
Risk Factors
Chemical
Reg. No./Substance:
0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoproteins, HDL; 0/very high density lipoproteins

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