Document Detail


Relationship of antioxidant enzyme activities with myelomeningocele.
MedLine Citation:
PMID:  22664996     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIM: To investigate the role of erythrocyte free radical scavenging enzyme activities (FRSE), carbonic anhydrase (CA) activity and malondialdehyde (MDA) in infants with myelomeningocele (MM). MATERIAL and
METHODS: We compared antioxidant enzyme activities and MDA level in 40 individuals (10 infants with MM, 10 healthy infants; and mothers of these two groups) with age-matched subjects. Erythrocyte FRSE included catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-S- transferase (GST).
RESULTS: CA, CAT, SOD, GPX and GST concentrations were lower in all of the infants with MM compared to healthy infants. The mothers of infants with MM also had lower CA, CAT, SOD, GPX and GST activities than healthy mothers. It was also found out that the MDA level as a marker of oxidative damage was higher in infants with MM and their mothers than in healthy infants and their mothers.
CONCLUSION: Lower FRSE activities indicate an increased frequency of MM. Free radicals (FRs) such as MDA may play a significant role in the etiology of MM.
Authors:
Mehmet Arslan; Mehmet Melek; Halit Demir; Metehan Eseoglu; Burhan Oral Gudu; Ismail Demir; Cigdem Cetin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Turkish neurosurgery     Volume:  22     ISSN:  1019-5149     ISO Abbreviation:  Turk Neurosurg     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423821     Medline TA:  Turk Neurosurg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  300-4     Citation Subset:  IM    
Affiliation:
Yuzuncu Yil University, Faculty of Medicine, Department of Neurosurgery, Van, Turkey.
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