| Relationship among maternal serum endocrinology, placental karyotype, and intervillous circulation in early pregnancy failure. | |
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MedLine Citation:
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PMID: 12798885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the relationship among maternal serum endocrinology, placental karyotype, and intervillous blood flow in missed miscarriage. DESIGN: Cross-sectional study of maternal serum, transvaginal ultrasound/Doppler, and placental cytogenetic and immunohistochemical investigations. SETTING: Tertiary care academic hospital. PATIENT(S): One hundred fifty-two women with missed miscarriage between 7 and 13 weeks of gestation. INTERVENTION(S): Ultrasound features, placental intervillous circulation findings on color Doppler imaging, and maternal serum level of alpha-fetoprotein (AFP), beta-hCG, E(2), P, and inhibin A were compared retrospectively with placenta karyotype and hCG immunochemistry. MAIN OUTCOME MEASURES: Data were analyzed according to karyotype results, presence or absence of an intervillous circulation, and delay between fetal demise and evacuation. RESULT(S): The presence of intervillous blood flow and serum concentrations of the different hormones were independent of placental karyotype. Serum beta-hCG and P were significantly higher in cases with intervillous blood flow. No difference in immunostaining for beta-hCG was found between placental tissues from normal pregnancies and missed miscarriages, but significantly higher villous beta-hCG content was found on Western blotting in miscarriage with a recent fetal demise. CONCLUSION(S): The excessive entry of maternal blood inside the placenta in the early stage of most miscarriages is unrelated to conceptus karyotype, and hCG features may reflect a temporary attempt of the trophoblast to stabilize after the initial oxidative insult. |
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Authors:
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Natalie Greenwold; Eric Jauniaux; Beatrice Gulbis; Joanne Hempstock; Christine Gervy; Graham J Burton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fertility and sterility Volume: 79 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-11 Completed Date: 2003-07-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1373-9 Citation Subset: IM |
Affiliation:
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Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, UCL Campus, London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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etiology* Cell Differentiation Chorionic Gonadotropin, beta Subunit, Human / blood Chorionic Villi / blood supply* Chromosome Aberrations* Cross-Sectional Studies Estradiol / blood Female Gestational Age Humans Immunohistochemistry Inhibins / blood Karyotyping Placenta / ultrastructure* Pregnancy / blood* Regional Blood Flow |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin, beta Subunit, Human; 0/inhibin B; 50-28-2/Estradiol; 57285-09-3/Inhibins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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