| Relationship of ambulatory arterial stiffness index with blood pressure response to exercise in the early stages of hypertension. | |
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MedLine Citation:
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PMID: 20216408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to investigate the plausible interrelationship of exaggerated blood pressure response during exercise (EBPR) with ambulatory arterial stiffness index (AASI) in never-treated patients with uncomplicated essential hypertension. METHODS: Ninety-nine never-treated hypertensive patients (aged 50.7 years, 61 male) underwent 24 h ambulatory blood pressure (BP) recording, complete echocardiographic study and treadmill exercise testing and were classified as patients with (n=36) and without EBPR (n=63) based on the systolic BP elevation at peak exercise (>or=210 mmHg for men and >or=190 mmHg for women). Arterial stiffness was evaluated by means of both AASI and pulse wave velocity (PWV). RESULTS: Hypertensives with EBPR, compared with those without EBPR, exhibited significantly higher 24 h systolic BP and pulse pressure (by 3.8 mmHg, P=0.041 and by 7.2 mmHg, P<0.001, respectively), and decreased peak early diastolic velocity and peak early diastolic velocity/peak atrial systolic velocity ratio (by 1.1 cm/s and by 0.11, both P<0.05, respectively). PWV and AASI values were higher in the EBPR group compared with the normal response group independently of confounders (by 0.9 m/s, P<0.001 and by 0.06, P=0.043, respectively). PWV (beta=0.308, P=0.008) and 24-h pulse pressure (beta=0.297, P=0.010), but not AASI, were independently associated with peak exercise systolic BP. CONCLUSION: EBPR constitutes a sign of premature cardiovascular stiffening in the setting of uncomplicated hypertension. The close relationship between EBPR and PWV but not AASI enhances the concept of PWV as a superior measure of arterial stiffness and constitutes an important factor in the interpretation of EBPR-linked cardiovascular risk. |
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Authors:
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Dimitris Tsiachris; Costas Tsioufis; Kyriakos Dimitriadis; Peter Kokkinos; Charles Faselis; Dimitris Tousoulis; Andreas Michaelides; Vasilios Papademetriou; Christodoulos Stefanadis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood pressure monitoring Volume: 15 ISSN: 1473-5725 ISO Abbreviation: Blood Press Monit Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-13 Completed Date: 2010-08-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606438 Medline TA: Blood Press Monit Country: England |
Other Details:
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Languages: eng Pagination: 132-8 Citation Subset: IM |
Affiliation:
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First Cardiology Clinic, Hippokration Hospital, University of Athens Medical School, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity* Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory Elasticity Exercise / physiology* Exercise Test Female Humans Hypertension / pathology, physiopathology* Male Middle Aged Pulsatile Flow* Vascular Resistance |
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