Document Detail

Relationship of aluminum to neurocognitive dysfunction in chronic dialysis patients.
MedLine Citation:
PMID:  3178374     Owner:  NLM     Status:  MEDLINE    
Aluminum has been proposed as the causative agent in dialysis encephalopathy syndrome. We prospectively assessed whether other, less severe, neuropsychologic abnormalities were also associated with aluminum. A total of 16 patients receiving chronic dialytic therapy were studied. The deferoxamine infusion test (DIT) was used to assess total body aluminum burden. Neurologic function was evaluated by quantitative measures of asterixis, myoclonus, motor strength, and sensation. Cognitive function was assessed by measures of dementia, memory, language, and depression. There were four patients with a positive DIT (greater than 125 micrograms/L increment in serum aluminum) that was associated with an increase in the number of neurologic abnormalities observed, as well as an increase in severity of myoclonus, asterixis, and lower extremity weakness. Patients with a positive DIT also showed significant impairment in memory; however, no differences were noted on tests of dementia, depression, or language. There was no significant correlation between sex, age, presence of diabetes, mode of dialysis, years of chronic renal failure, years of dialysis or years of aluminum ingestion and any neurologic or neurobehavioral measurement, serum aluminum level, or DIT. These changes may represent early aluminum-associated neurologic dysfunction.
S M Sprague; H L Corwin; C M Tanner; R S Wilson; B J Green; C G Goetz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  148     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-11-10     Completed Date:  1988-11-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2169-72     Citation Subset:  AIM; IM    
Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL.
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MeSH Terms
Aluminum / metabolism,  poisoning*
Body Burden
Cognition Disorders / blood,  chemically induced*
Deferoxamine / diagnostic use
Middle Aged
Neuromuscular Diseases / blood,  chemically induced*
Prospective Studies
Renal Dialysis / adverse effects*
Time Factors
Reg. No./Substance:
70-51-9/Deferoxamine; 7429-90-5/Aluminum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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