| Relationship of actin, microtubules, and crosswall synthesis during septation in Aspergillus nidulans. | |
| | |
MedLine Citation:
|
PMID: 9415379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Studies of cytokinesis in animal cells demonstrate that microtubules play an important role in signaling the position of the actin-containing contractile ring and subsequent formation of the cleavage furrow. Septation in several fungi closely resembles animal cell cytokinesis in that a circumferential ring of actin is visible at the incipient division site. However, this does not necessarily mean that division is contractile since actin may also serve to localize septal wall synthesis. In addition, several studies in fission yeast have suggested that microtubules are dispensable for actin ring formation. We have used synchronized cells and fluorescence microscopy to follow actin structures, nuclear division and septal wall synthesis during septation in Aspergillus nidulans. Our data suggest that actin first appears at the septum site as a circumferential ring and that it later broadens and invaginates, forming an hourglass-shaped structure coincident with septal cell wall synthesis. Depolymerization of microtubules early in septation prevents circumferential actin ring formation. Depolymerization of microtubules after circumferential actin ring formation blocks both the progression to invaginating bands and septal wall synthesis. In contrast to studies in yeast cells, our data suggest that microtubules are required for both the initiation and progression of septation in A. nidulans. |
| | |
Authors:
|
M Momany; J E Hamer |
Related Documents
:
|
12686629 - Analysis of microtubules and f-actin structures in hyphae and conidia development of th... 9792999 - Induction and enhancement of normal human megakaryocyte polyploidization are concomitan... 12658439 - Expression of vasp and zyxin in cochlear pillar cells: indication for actin-based dynam... 8970159 - Ng2 proteoglycan and the actin-binding protein fascin define separate populations of ac... 19961849 - Effects of chemical inhibition of n-wasp, a critical regulator of actin polymerization ... 19213599 - Dictyostelium discoideum paxillin regulates actin-based processes. 12553029 - Expression of surface protein receptors in lung cancer. 3785549 - Glycolipid modulation of membrane adhesion. 21783219 - Resveratrol supplementation abrogates pro-arteriogenic effects of intramyocardial vascu... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Cell motility and the cytoskeleton Volume: 38 ISSN: 0886-1544 ISO Abbreviation: Cell Motil. Cytoskeleton Publication Date: 1997 |
Date Detail:
|
Created Date: 1998-02-12 Completed Date: 1998-02-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8605339 Medline TA: Cell Motil Cytoskeleton Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 373-84 Citation Subset: IM |
Affiliation:
|
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-1392, USA. momany@dogwood.botany.uga.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Actins
/
physiology* Aspergillus nidulans / metabolism, physiology*, ultrastructure Cell Division / physiology Cell Wall / physiology Chitin / metabolism Microtubules / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Actins; 1398-61-4/Chitin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Jasplakinolide, a novel actin targeting peptide, inhibits cell growth and induces actin filament pol...
Next Document: Type II myosin involved in cytokinesis in the fission yeast, Schizosaccharomyces pombe.