Document Detail

Relationship of Smoking and/or Passive Exposure to Tobacco Smoke on the Association between Serum Thyroid-Stimulating Hormone and Body Mass Index in Large Groups of Adolescents and Children.
MedLine Citation:
PMID:  23046200     Owner:  NLM     Status:  Publisher    
Background: Hypothyroidism may be a risk factor for obesity, because metabolic rates tend to be decreased in this disorder. Currently it is under debate whether smoking may modify the association between hypothyroidism and obesity. Against this background the aims of our study were to investigate whether there is an association between serum thyroid-stimulating hormone (TSH) and body mass index (BMI) in children and adolescents and whether smoking mediates this association. Methods: Data from 6,435 children (ages 3 to 10) and 5,918 adolescents (ages 11 to 17) from the "The German Health Interview and Examination Survey for Children and Adolescents" (KiGGS) were analyzed. Smoking status was categorized into two categories, smokers and non-smokers. A subject was classified as being exposed to environmental tobacco smoke (ETS) if someone in the parental home smoked more than 1 day a week. Serum TSH levels were measured with an ELISA method. Serum TSH levels were associated with BMI and obesity by multivariable linear regression stratified by smoking status and exposure to ETS. Results: In adolescents, there was an association between serum TSH levels and BMI and it was stronger in smokers (β=0.62; 95%-confidence interval (CI)=0.38-0.85) than in non-smokers (β=0.18; CI=0.09-0.28). Likewise, it was stronger in adolescents exposed to ETS and adolescents not exposed to ETS. In children, who were either exposed or not exposed to ETS, there was an association between serum TSH levels and BMI. In them, however, the strength of this association was similar in those exposed and not exposed to ETS. Conclusions: Active and passive smoking may mediate the association between thyroid function and BMI in adolescents. In smoking adolescents hypothyroidism may lead to an increase of the BMI, whereas this is not the case in non-smoking adolescents.
Till Ittermann; Michael Thamm; Sabine Schipf; Ulrich John; Rainer Rettig; Henry Völzke
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-9
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  -     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Greifswald, Institute for Community Medicine, Walther-Rathenau-Str. 48, Greifswald, Germany, 17487, 00493834867539;
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