| Relationship of resting B-type natriuretic peptide level to cardiac work and total physical work capacity in heart failure patients. | |
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MedLine Citation:
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PMID: 19561522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Plasma B-type natriuretic peptide (BNP) levels obtained at rest have been previously shown to be correlated with the global functional capacity measures of peak oxygen uptake (V(O(2peak))) and the minute ventilation/carbon dioxide (VE/V(O(2))) slope. The purpose of this study was to assess the relationship of the plasma BNP level to the rate-pressure product (RPP) as an indicator of central or cardiac work capacity. METHODS: Twenty-two subjects (12 men), mean age 57 +/- 12 years, diagnosed with heart failure (8 ischemic/14 nonischemic) were recruited. All subjects were stable on optimal medical therapy for at least 1 month. Blood samples for BNP level analysis were obtained at rest. Subjects underwent a symptom-limited treadmill exercise test using a ramping protocol while V(O(2)), heart rate (HR), and blood pressure (BP) were monitored. Correlation analyses were conducted to assess the relationship of BNP level to RPP level, V(O(2peak), VE/V(O(2)) slope, end-tidal CO(2) pressure (P(ET)CO(2)), and left ventricular ejection fraction (LVEF). RESULTS: Resting BNP levels were significantly correlated with RPP levels (r = -0.69). The BNP level and the RPP level were correlated with V(O(2peak)) (r = -0.63 and r = 0.66, respectively) and VE/V(O(2)) slope (r = 0.53 and r = -0.54, respectively). The RPP level but not the BNP level was correlated with P(ET)CO(2) (r = 0.57). Neither BNP nor RPP levels were well correlated with LVEF (r = -0.26 and r = 0.14, respectively). DISCUSSION: The results of this study suggest that resting plasma BNP level may be a useful clinical measure for evaluating both global functional capacity and myocardial specific work capacity in individuals with heart failure. |
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Authors:
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Joseph F Norman; Bunny J Pozehl; Kathleen A Duncan; Melody A Hertzog; Ahmed S Elokda; Steven K Krueger |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of cardiopulmonary rehabilitation and prevention Volume: 29 ISSN: 1932-751X ISO Abbreviation: J Cardiopulm Rehabil Prev Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-02-18 Revised Date: 2011-09-07 |
Medline Journal Info:
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Nlm Unique ID: 101291247 Medline TA: J Cardiopulm Rehabil Prev Country: United States |
Other Details:
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Languages: eng Pagination: 310-3 Citation Subset: IM |
Affiliation:
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Division of Physical Therapy Education, University of Nebraska Medical Center, 984420 Nebraska Medical Center, Omaha, Nebraska 68198, USA. jfnorman@unmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Disease Progression Exercise Test Exercise Therapy / methods* Exercise Tolerance / physiology Female Fluoroimmunoassay Follow-Up Studies Heart Failure / blood*, physiopathology, rehabilitation Humans Male Middle Aged Motor Activity / physiology* Natriuretic Peptide, Brain / blood* Prognosis Rest / physiology* Stroke Volume / physiology* Ventricular Function, Left / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R-15 NR009215-01/NR/NINR NIH HHS; R15 NR009215-01/NR/NINR NIH HHS |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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