Document Detail


Relationship of P300 single-trial responses with reaction time and preceding stimulus sequence.
MedLine Citation:
PMID:  16364479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Variation of single-trial P300 responses was studied both in relation to reaction times and to the preceding stimulus sequence in an auditory oddball paradigm. Single-trial responses were estimated with the Subspace regularization method that is based on Bayesian estimation and linear modeling. The results of the single-trial method were compared to those of averaging. Both methods showed that the latency of the P300 was shorter and its amplitude larger for faster than slower reaction times. The P300 latency was shorter for target tones that were preceded by a large number of standard tones compared to those preceded by a small number of standard tones. The P300 amplitude was statistically significantly affected by the stimulus sequence only when analyzed with conventional averaging. In-depth analysis of standard deviations showed that the variability of the P300 single-trial latencies could explain the differences between the two methods. Specifically, the regression analysis showed that the latency correlated negatively with the number of preceding standard tones and positively with the reaction time, whereas the P300 amplitude correlated positively with the number of the preceding standard stimuli and negatively with the reaction time. The analysis of the single-trial responses gives information about the behavior of the P300 component that is lost with conventional averaging. The method used in this study is independent of subjective decision making and can be used to model changes in the dynamical behavior of the P300 component objectively.
Authors:
Anu Holm; Perttu O Ranta-aho; Mikael Sallinen; Pasi A Karjalainen; Kiti Müller
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-12-20
Journal Detail:
Title:  International journal of psychophysiology : official journal of the International Organization of Psychophysiology     Volume:  61     ISSN:  0167-8760     ISO Abbreviation:  Int J Psychophysiol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406214     Medline TA:  Int J Psychophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  244-52     Citation Subset:  IM    
Affiliation:
Brain Work Research Center, Finnish Institute of Occupational Health, 00250 Helsinki, Finland. anu.holm@ttl.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Arousal / physiology*
Attention / physiology*
Electroencephalography*
Event-Related Potentials, P300 / physiology*
Female
Humans
Mathematical Computing
Memory, Short-Term / physiology*
Pitch Discrimination / physiology*
Psychomotor Performance / physiology
Reaction Time / physiology*
Sensitivity and Specificity
Serial Learning / physiology
Signal Processing, Computer-Assisted*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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