Document Detail


Relationship of Neutrophil Gelatinase-associated Lipocalin (NGAL) and Procalcitonin Levels with the Presence and Severity of the Preeclampsia (NGAL & PCT in preeclampsia).
MedLine Citation:
PMID:  25283849     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: The aim of the present study was to evaluate changes in maternal serum Neutrophil Gelatinase-associated Lipocalin (NGAL) and procalcitonin (PCT) concentrations in preeclampsia. Material and method: This case-control study consisted of 40 preeclamptic and 40 healthy singleton pregnancies matched for age and body mass index. Serum NGAL and PCT levels were compared between the groups. Diagnostic performance and clinical association of these markers were evaluated. Results: NGAL and PCT concentrations were significantly higher in preeclamptic group (p< 0.0001 and p= 0.001, respectively) and their levels were correlated with the severity of the preeclampsia. There were significant positive correlation between these markers and mean arterial pressure (MAP) and spot urine protein excretion. There was negative correlation between NGAL and apgar scores and fetal birth weight. Pregnancies with higher NGAL (OR: 4.89; 95% CI: 1.81-13.21) and higher PCT (OR:6.67; 95% CI:2.44-18.21) concentrations had higher risk for preeclampsia. Conclusion: NGAL and PCT may be potential biomarkers for preeclampsia. Their levels increase significantly in preeclampsia and they are related to the severity of the disease. These results are in agreement with the generalized endothelial damage and persistant inflammatory status in preeclampsia. NGAL may be also an indicator for adverse neonatal outcomes with decreased placental hypoperfusion.
Authors:
Burcu Artunc Ulkumen; Yesim Guvenc; Asli Goker; Ceyhun Gozukara
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-6
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-6     Completed Date:  -     Revised Date:  2014-10-7    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-20     Citation Subset:  -    
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