| Relationship of low-circulating "anti-aging" klotho hormone with disability in activities of daily living among older community-dwelling adults. | |
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MedLine Citation:
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PMID: 22530731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aging suppressor gene klotho encodes a single-pass transmembrane protein klotho that in mice is known to extend life span when overexpressed and to resemble accelerated aging, with skeletal muscle atrophy and decreased bone mineral density, when expression is disrupted. We sought to examine the relationship between plasma klotho and disability in activities of daily living (ADL) in older community-dwelling adults. In a cross-sectional study, plasma klotho was measured in a population-based sample of 802 adults, ≥ 65 years, who participated in the "Invecchiare in Chianti" (Aging in the Chianti Area) (InCHIANTI) study in Tuscany, Italy. The overall proportion of adults with ADL disability was 11.9%. Mean (standard deviation) klotho concentrations were 689 (238) pg/mL. From the lowest to the highest tertile of plasma klotho, 16.1%, 9.7%, and 5.6% of participants, respectively, had ADL disability (p=0.0004). Plasma klotho, per 1 standard deviation increase, was associated with ADL disability (odds ratio=0.57, 95% confidence interval 0.35-0.93, p=0.02) in a multivariate logistic regression model adjusting for age, education, cognition, physical activity, physical performance, total cholesterol, alcohol and tobacco use, and chronic diseases. Low plasma klotho concentrations were independently associated with ADL disability among older community-dwelling men and women. |
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Authors:
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Candace L Crasto; Richard D Semba; Kai Sun; Anne R Cappola; Stefania Bandinelli; Luigi Ferrucci |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2012-04-24 |
Journal Detail:
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Title: Rejuvenation research Volume: 15 ISSN: 1557-8577 ISO Abbreviation: Rejuvenation Res Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-07-04 Completed Date: 2013-01-31 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: United States |
Other Details:
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Languages: eng Pagination: 295-301 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living* Adult Aged Aged, 80 and over Aging / blood* Animals Disabled Persons* Female Glucuronidase / blood* Humans Logistic Models Male Mice Multivariate Analysis Residence Characteristics* |
| Grant Support | |
ID/Acronym/Agency:
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263 MD 821336/MD/NIMHD NIH HHS; 263 MD 9164/MD/NIMHD NIH HHS; N.1-AG-1-1/AG/NIA NIH HHS; N.1-AG-1-2111/AG/NIA NIH HHS; N01-AG-5-0002/AG/NIA NIH HHS; R01 AG027012/AG/NIA NIH HHS; R01 HL094507/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.2.1.31/Glucuronidase; EC 3.2.1.31/klotho protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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