| Relationship of Kaposi sarcoma (KS)-associated herpesvirus viremia and KS disease in Zimbabwe. | |
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MedLine Citation:
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PMID: 12715309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between Kaposi sarcoma-associated herpesvirus (KSHV) viremia and KS disease was investigated in 500 subjects who received treatment in Harare, Zimbabwe. Subjects were grouped by results of human immunodeficiency virus (HIV) type 1 serological tests, KS diagnosis, and KS clinical stage. The plasma KSHV DNA concentration was associated with concomitant KS and HIV-1 infection (AIDS-KS; P<.001) and AIDS-KS clinical stage (P=.01). Plasma KSHV DNA levels were greater in AIDS-KS than in matched HIV-1-seronegative KS (P=.04). The plasma KSHV DNA level was not associated with age, sex, systemic symptoms, or CD4+ lymphocyte count. Plasma and peripheral blood mononuclear cell KSHV DNA concentrations were linearly related (r2=.44; P<.001), and the nucleotide sequence of the K1 gene highly variable region was identical in both compartments. These findings provide evidence that KSHV viremia is common in advanced AIDS-KS in Zimbabwe and suggest a relationship between KSHV lytic replication and untreated HIV-1 infection. |
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Authors:
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Thomas B Campbell; Margaret Borok; Irene E White; Ivy Gudza; Buxton Ndemera; Albert Taziwa; Adriana Weinberg; Lovemore Gwanzura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2003-04-22 |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 36 ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-25 Completed Date: 2003-05-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1144-51 Citation Subset: IM |
Affiliation:
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Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged DNA, Viral / analysis Endemic Diseases Female Genetic Variation Herpesvirus 8, Human / genetics, isolation & purification* Humans Male Middle Aged Sarcoma, Kaposi / blood, complications* Viremia / blood, complications* Zimbabwe / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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CA79389/CA/NCI NIH HHS; TW0123/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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