Document Detail


Relationship of carotid distensibility and thoracic aorta calcification: multi-ethnic study of atherosclerosis.
MedLine Citation:
PMID:  19805639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stiffening of the central elastic arteries is one of the earliest detectable manifestations of adverse change within the vessel wall. Although an association between carotid artery stiffness and adverse events has been demonstrated, little is known about the relationship between stiffness and atherosclerosis. Even less is known about the impact of age, sex, and race on this association. To elucidate this question, we used baseline data from the Multi-Ethnic Study of Atherosclerosis (2000-2002). Carotid artery distensibility coefficient was calculated after visualization of the instantaneous waveform of the common carotid diameter using a high-resolution B-mode ultrasound. Thoracic aorta calcification was identified using noncontrast cardiac computed tomography. We found a strong association between decreasing distensibility coefficient (increasing carotid stiffness) and increasing thoracic aorta calcification, as well as a graded increase in the thoracic aorta calcification score (P<0.001). After controlling for age, sex, race, and traditional and emerging cardiovascular risk factors, individuals in the stiffest quartile had a prevalence ratio of 1.52 (95% CI: 1.15 to 2.00) for thoracic aorta calcification compared with the least stiff quartile. In exploratory analysis, carotid stiffness was more highly correlated with calcification of the aorta than calcification of the coronary arteries (rho=0.32 versus 0.22; P<0.001 for comparison). In conclusion, there is a strong independent association between carotid stiffness and thoracic aorta calcification. Carotid stiffness is more highly correlated with calcification of the aorta, a central elastic artery, than calcification of the coronary arteries. The prognostic significance of these findings requires longitudinal follow-up of the Multi-Ethnic Study of Atherosclerosis cohort.
Authors:
Michael J Blaha; Matthew J Budoff; Juan J Rivera; Ronit Katz; Daniel H O'Leary; Joseph F Polak; Junichiro Takasu; Roger S Blumenthal; Khurram Nasir
Related Documents :
7670749 - Triglyceride-rich lipoproteins and the progression of coronary artery disease.
2018799 - Modifications of low-density lipoprotein induced by arterial proteoglycans and chondroi...
8217039 - Arterial thrombosis: putative role of lipoprotein(a).
16386259 - Endothelial function in hypercholesterolemic subjects: effects of plant stanol and ster...
10592139 - Environmental tobacco smoke and measures of subclinical vascular disease.
14739049 - Tissue characterization identifies subjects with high risk of cardiovascular diseases.
20028909 - Assessment of in-stent restenosis using 64-mdct: analysis of the core-64 multicenter in...
10629259 - The use of gastric tonometry in the assessment of celiac artery compression syndrome.
8518829 - The ideal ureteral stent for antegrade and retrograde endopyelotomy: what would it be l...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-10-05
Journal Detail:
Title:  Hypertension     Volume:  54     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2009-12-17     Revised Date:  2014-08-27    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1408-15     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group / statistics & numerical data
Aged
Aged, 80 and over
Aorta, Thoracic / radiography
Aortic Diseases / ethnology*,  radiography
Asian Americans / statistics & numerical data
Atherosclerosis / ethnology*,  radiography,  ultrasonography
Calcinosis / ethnology*,  radiography,  ultrasonography
Carotid Arteries / ultrasonography
Carotid Artery Diseases / ethnology*,  ultrasonography
Elasticity
Ethnic Groups / statistics & numerical data*
European Continental Ancestry Group / statistics & numerical data
Female
Hispanic Americans / statistics & numerical data
Humans
Male
Middle Aged
Models, Cardiovascular
Multivariate Analysis
Prevalence
Risk Factors
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
L30 HL110027/HL/NHLBI NIH HHS; N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; R01 HL071739/HL/NHLBI NIH HHS; T32 HL007227/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Angiotensin Receptor Blocker Prevented {beta}-Amyloid-Induced Cognitive Impairment Associated With R...
Next Document:  Mediterranean-style diet effect on the structural properties of the erythrocyte cell membrane of hyp...