Document Detail


Relationship of C-reactive protein to presence and severity of coronary atherosclerosis in patients with stable angina pectoris or a pathological exercise test.
MedLine Citation:
PMID:  12131018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: C-reactive protein (CRP) level is a sensitive marker of inflammation and a probable predictor of cardiovascular risk. The aim of this study was to assess the relationship between the presence and the extent of coronary atherosclerosis and CRP level in patients referred for coronary angiography for stable angina pectoris or a pathological exercise test. PATIENTS AND METHODS: A group of 200 patients were prospectively analyzed for the relationship between the presence and extent of coronary atherosclerosis and high-sensitivity CRP. Patients with stable angina pectoris or a pathological exercise test were included. RESULTS: For the whole group the CRP geometric mean was 2.92 mg/l and the median 3.0 mg/l. There was no difference between groups of patients with different extents of coronary lesions (P = 0.320, one-way analysis of variance). In patients without significant coronary disease the CRP geometric mean was 3.1 (2.28-4.21) mg/l with a variation coefficient of 118.4%; in patients with coronary artery disease the geometric mean was 2.83 (2.34-3.43) mg/l with a variation coefficient of 104.0%. The difference in CRP between both groups was not significant (P = 0.601). There was also no significant difference in CRP levels between groups of patients with and without a history of myocardial infarction (2.65 (2.08-3.36) mg/l and 3.18 (2.54-3.98) mg/l, P = 0.266) respectively. There was no correlation between the classification of angina pectoris and the logarithm of CRP level (P = 0.331). This relationship was not confirmed even in the group of patients with significant coronary artery disease (P = 0.693). CONCLUSIONS: CRP level is not related to the extent or the presence of coronary atherosclerosis assessed by coronary angiography, history of myocardial infarction or class of stable angina pectoris in patients referred for coronary angiography for stable angina pectoris or a pathological exercise test.
Authors:
Josef Veselka; Sárka Procházková; Radka Duchonová; Ingrid Bolomová; Tat'ána Urbanová; David Tesar; Tomás Honek
Related Documents :
1576038 - Nitrates.
8115978 - Prothrombin activation fragment 1 + 2 and thrombin antithrombin iii complexes in patien...
25181728 - Cardiomyopathy induced by sinus tachycardia in combat wounded: a case study.
21282558 - An oral formulation of angiotensin-(1-7) produces cardioprotective effects in infarcted...
23566678 - Comparison of the novel medtentia double helix mitral annuloplasty system with the carp...
9673658 - Mediators of restenosis.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  13     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-07-19     Completed Date:  2002-09-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  151-4     Citation Subset:  IM    
Affiliation:
Division of Cardiac Surgery, University Hospital Motol, Prague, Czech Republic. veselka.josef@seznam.cz
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / complications*,  metabolism*
C-Reactive Protein / metabolism*
Coronary Angiography
Coronary Artery Disease / complications*,  metabolism*
Cross-Sectional Studies
Exercise Test*
Female
Humans
Male
Middle Aged
Myocardial Infarction / complications,  metabolism
Severity of Illness Index
Statistics as Topic
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of low-dose dobutamine stress echocardiography and echocardiography during glucose-insuli...
Next Document:  Coronary collateralization: determinants of adequate distal vessel filling after arterial occlusion.