Document Detail


Relationship between white-matter hyperintensities and hematoma volume and growth in patients with intracerebral hemorrhage.
MedLine Citation:
PMID:  19926840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: The presence of white-matter hyperintensities (WMHs) has been linked to intracerebral hemorrhage (ICH). We sought to determine whether the severity of WMHs influences hematoma growth and ICH volume.
METHODS: We retrospectively reviewed prospectively collected clinical, laboratory, and radiologic data from 79 consecutive ICH patients who had brain magnetic resonance imaging performed within 72 hours of ICH symptom onset. We assessed the severity of WMHs on magnetic resonance imaging on the modified Scheltens scale and performed logistic-regression analysis to examine the association between WMHs and ICH volume. We also examined the association between WMH score and hematoma growth in a subset of 34 patients who had a baseline computed tomography scan within 12 hours of ICH onset and a follow-up scan within 72 hours.
RESULTS: The ICH volume at 37.6+/-22.3 hours from ICH onset was 2-fold higher in patients with a high WMH score (> or =14) than in those with a lower score. A high WMH score was independently associated with a larger ICH volume (odds ratio=1.152; 95% CI, 1.035 to 1.282; P=0.01). There was a trend for an association between WMH score and ICH volume growth (odds ratio=1.286; 95% CI, 0.978 to 1.692; P=0.062).
CONCLUSIONS: Severe WMHs are associated with larger ICH volumes and, to a lesser extent, with hematoma growth. Our findings suggest that WMHs may provide important prognostic information on patients with ICH and may have implications for treatment stratification. These findings require prospective validation, and the links between WMHs and ICH growth require further investigations.
Authors:
Min Lou; Adel Al-Hazzani; Richard P Goddeau; Vera Novak; Magdy Selim
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2009-11-19
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  41     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-29     Completed Date:  2010-01-28     Revised Date:  2011-11-21    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-40     Citation Subset:  IM    
Affiliation:
Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cerebral Hemorrhage / complications,  pathology*
Female
Hematoma, Epidural, Cranial / complications,  pathology*
Humans
Leukoaraiosis / complications,  pathology*
Male
Middle Aged
Nerve Fibers, Myelinated / pathology*
Prospective Studies
Retrospective Studies
Risk Factors
Grant Support
ID/Acronym/Agency:
1R01-NS 057127-01A1/NS/NINDS NIH HHS; 1R01-NS045745-01A2/NS/NINDS NIH HHS; R01 NS045745-04/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined popula...
Next Document:  Postthrombolysis Blood Pressure Elevation Is Associated With Hemorrhagic Transformation.