| Relationship between white-matter hyperintensities and hematoma volume and growth in patients with intracerebral hemorrhage. | |
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MedLine Citation:
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PMID: 19926840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The presence of white-matter hyperintensities (WMHs) has been linked to intracerebral hemorrhage (ICH). We sought to determine whether the severity of WMHs influences hematoma growth and ICH volume. METHODS: We retrospectively reviewed prospectively collected clinical, laboratory, and radiologic data from 79 consecutive ICH patients who had brain magnetic resonance imaging performed within 72 hours of ICH symptom onset. We assessed the severity of WMHs on magnetic resonance imaging on the modified Scheltens scale and performed logistic-regression analysis to examine the association between WMHs and ICH volume. We also examined the association between WMH score and hematoma growth in a subset of 34 patients who had a baseline computed tomography scan within 12 hours of ICH onset and a follow-up scan within 72 hours. RESULTS: The ICH volume at 37.6+/-22.3 hours from ICH onset was 2-fold higher in patients with a high WMH score (> or =14) than in those with a lower score. A high WMH score was independently associated with a larger ICH volume (odds ratio=1.152; 95% CI, 1.035 to 1.282; P=0.01). There was a trend for an association between WMH score and ICH volume growth (odds ratio=1.286; 95% CI, 0.978 to 1.692; P=0.062). CONCLUSIONS: Severe WMHs are associated with larger ICH volumes and, to a lesser extent, with hematoma growth. Our findings suggest that WMHs may provide important prognostic information on patients with ICH and may have implications for treatment stratification. These findings require prospective validation, and the links between WMHs and ICH growth require further investigations. |
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Authors:
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Min Lou; Adel Al-Hazzani; Richard P Goddeau; Vera Novak; Magdy Selim |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2009-11-19 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 41 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-29 Completed Date: 2010-01-28 Revised Date: 2011-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 34-40 Citation Subset: IM |
Affiliation:
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Second Affiliated Hospital of Zhejiang University, Hangzhou, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Cerebral Hemorrhage / complications, pathology* Female Hematoma, Epidural, Cranial / complications, pathology* Humans Leukoaraiosis / complications, pathology* Male Middle Aged Nerve Fibers, Myelinated / pathology* Prospective Studies Retrospective Studies Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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1R01-NS 057127-01A1/NS/NINDS NIH HHS; 1R01-NS045745-01A2/NS/NINDS NIH HHS; R01 NS045745-04/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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