Document Detail

The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: findings from NHANES III, 1988 to 1994.
MedLine Citation:
PMID:  21200000     Owner:  NLM     Status:  MEDLINE    
Recent data suggest that visit-to-visit variability of blood pressure is associated with stroke incidence. Correlates of increased visit-to-visit variability in blood pressure and the relationship between variability and all-cause mortality were examined using data on US adults ≥ 20 years of age from the Third National Health and Nutrition Examination Survey (n = 956). Three consecutive blood pressure readings were taken during 3 separate study visits from 1988 to 1994. Based on the mean of the second and third measurements from each visit, visit-to-visit blood pressure variability for each participant was defined using the standard deviation and coefficient of variation across visits. Mortality was assessed through December 31, 2006 (median follow-up = 14 years; n = 240 deaths). The mean of the standard deviation for systolic blood pressure across visits was 7.7 mm Hg. After multivariable adjustment, older age, female gender, history of myocardial infarction, higher mean systolic blood pressure and pulse pressure, and use of angiotensin converting enzyme inhibitors were associated with higher standard deviation in systolic blood pressure. The multivariable adjusted hazard ratios for all-cause mortality associated with a standard deviation of systolic blood pressure of 4.80 to 8.34 mm Hg and ≥ 8.35 mm Hg, versus <4.80 mm Hg, were 1.57 (95% CI, 1.07 to 2.18) and 1.50 (95% CI, 1.03 to 2.18), respectively. Results were similar when coefficient of variation for systolic blood pressure was evaluated. Visit-to-visit variability for diastolic blood pressure was not associated with mortality. In this population-based study of US adults, higher levels of short-term visit-to-visit variability in systolic blood pressure were associated with increased all-cause mortality.
Paul Muntner; Daichi Shimbo; Marcello Tonelli; Kristi Reynolds; Donna K Arnett; Suzanne Oparil
Publication Detail:
Type:  Journal Article     Date:  2011-01-03
Journal Detail:
Title:  Hypertension     Volume:  57     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-20     Completed Date:  2011-04-22     Revised Date:  2011-09-29    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-6     Citation Subset:  IM    
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Blood Pressure / drug effects,  physiology*
Cause of Death
Follow-Up Studies
Health Surveys / statistics & numerical data
Hypertension / drug therapy,  mortality,  physiopathology*
Linear Models
Middle Aged
Multivariate Analysis
Office Visits*
Proportional Hazards Models
Risk Factors
United States / epidemiology
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors
Comment In:
Hypertension. 2011 Jul;58(1):e1; author reply e2   [PMID:  21576626 ]
Hypertension. 2011 Sep;58(3):e16   [PMID:  21810654 ]
Hypertension. 2011 Feb;57(2):141-3   [PMID:  21199992 ]

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