Document Detail

Relationship Between Patterns of Intermittent Hypoxia and Retinopathy of Prematurity in Preterm Infants.
MedLine Citation:
PMID:  23037873     Owner:  NLM     Status:  Publisher    
Background:We have previously shown an increased incidence of intermittent hypoxemic events (IH) in preterm infants with severe retinopathy of prematurity (ROP). Animal models suggest that patterns of IH events may play a role in ROP severity as well. We hypothesize that specific IH patterns are associated with ROP in preterm infants.Methods:Variability in IH duration, severity and the time interval between IH (≤80%, ≥10 seconds and ≤3min) along with the frequency spectrum of the oxygen saturation (SpO(2)) waveform were assessed.Results:Severe ROP was associated with 1) an increased mean and standard deviation of the duration of IH (p<0.005), 2) more variability (Histogram Entropy) of the time interval between IH (p<0.005), 3) a higher IH nadir (p<0.05), 4) a time interval between IH of 1-20min (p<0.05) and 5) increased spectral power in the range of 0.002-0.008Hz (p<.05), corresponding to SpO(2) waveform oscillations of 2-8 minutes in duration. Spectral differences were detected as early as 14 days of life.Conclusions:Severe ROP was associated with more variable, longer, and less severe IH events. Identification of specific spectral components in the SpO(2) waveform may assist in early identification of infants at risk for severe ROP.Pediatric Research (2012); doi:10.1038/pr.2012.132.
Juliann M Di Fiore; Farhad Kaffashi; Kenneth Loparo; Abdus Sattar; Mark Schluchter; Ryan Foglyano; Richard J Martin; Christopher G Wilson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-04
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH 44106.
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