Document Detail


Relationship between patterns of alcohol consumption and gastrointestinal symptoms among patients with irritable bowel syndrome.
MedLine Citation:
PMID:  23295280     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Heavy alcohol intake may exacerbate gastrointestinal (GI) symptoms in adults with irritable bowel syndrome (IBS); however, the role of alcohol in IBS is unclear. We investigated prospective associations between daily patterns of alcohol intake and next day's GI symptoms using daily diaries.
METHODS: In an observational study of women aged 18-48 years with IBS and healthy controls, participants recorded daily GI symptoms, alcohol intake, caffeine intake, and cigarette smoking for ≈ 1 month. GI symptoms included abdominal pain, abdominal bloating, intestinal gas, diarrhea, constipation, nausea, stomach pain, heartburn, and indigestion. Binge drinking was defined as 4+ alcohol-containing drinks/day.
RESULTS: Patterns of alcohol intake did not differ between IBS patients and controls. Although patterns of drinking were associated with GI symptoms among women with IBS, this was not the case with the healthy controls. The strongest associations for IBS patients were between binge drinking and the next day's GI symptoms (e.g., diarrhea, P=0.006; nausea, P=0.01; stomach pain, P=0.009; and indigestion, P=0.004), whereas moderate and light drinking either were not associated or weakly associated with GI symptoms. Associations between alcohol intake and GI symptoms were stronger for women with IBS-diarrhea than for IBS-constipation or IBS-mixed. Effects of binge drinking on GI symptoms were strongest when comparing between individuals (rather than within individuals).
CONCLUSIONS: Our findings indicate that IBS symptoms differ according to the pattern of alcohol intake among IBS patients, suggesting that the pattern of drinking may in part explain the inconsistent findings between alcohol and IBS symptoms.
Authors:
Kerryn W Reding; Kevin C Cain; Monica E Jarrett; Margaret D Eugenio; Margaret M Heitkemper
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-08
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  108     ISSN:  1572-0241     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-03-22     Revised Date:  2013-08-09    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-6     Citation Subset:  IM    
Affiliation:
Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, Washington 98195-7260, USA. kreding@uw.edu
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MeSH Terms
Descriptor/Qualifier:
Abdominal Pain / etiology
Adult
Alcohol Drinking / adverse effects
Binge Drinking / complications*
Caffeine / administration & dosage
Case-Control Studies
Coffee / adverse effects
Constipation / etiology
Diarrhea / etiology
Digestive System / drug effects*,  physiopathology*
Dyspepsia / etiology
Ethanol / administration & dosage,  adverse effects*
Female
Flatulence / etiology
Heartburn / etiology
Humans
Irritable Bowel Syndrome / complications*
Middle Aged
Models, Statistical
Nausea / etiology
Prospective Studies
Questionnaires
Risk Factors
Smoking / adverse effects
Grant Support
ID/Acronym/Agency:
K99 NR012232/NR/NINR NIH HHS; K99NR012232/NR/NINR NIH HHS; NR04101/NR/NINR NIH HHS; NR04142/NR/NINR NIH HHS; P30 NR004001/NR/NINR NIH HHS; R01 NR004142/NR/NINR NIH HHS
Chemical
Reg. No./Substance:
0/Coffee; 58-08-2/Caffeine; 64-17-5/Ethanol
Comments/Corrections

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