Document Detail

Relationship between oral amiodarone and inappropriate therapy from an implantable cardioverter defibrillator.
MedLine Citation:
PMID:  20484827     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study evaluated the efficacy of amiodarone for avoiding inappropriate therapies by implantable cardioverter defibrillators (ICDs).
METHODS AND RESULTS: A total of 232 patients with structural heart disease (58+/-13 years; 78% males) who underwent an initial ICD implantation were retrospectively investigated to compare baseline characteristics and event rates of inappropriate ICD therapy delivery between patients with oral amiodarone therapy (amiodarone group, n=116) and those without (non-amiodarone group, n=116). During a mean follow-up of 29+/-21 months, inappropriate therapies occurred less frequently in the amiodarone group than in the non-amiodarone group (12% vs 27%, P=0.0068). As a cause of inappropriate ICD therapy, only atrial fibrillation (AF) significantly differed between the groups (3% vs 12%, P=0.01). The results of multivariate logistic regression analysis showed that amiodarone therapy (odds ratio (OR) 0.38, 95% confidence interval (CI) 0.19-0.77, P=0.0073) and no history of spontaneous AF (OR 0.27, 95%CI 0.13-0.57, P=0.0007) were independent predictors of a lower risk of inappropriate ICD therapy.
CONCLUSIONS: In the present group of ICD patients with structural heart disease, inappropriate therapy delivery occurred predominantly in those with spontaneous AF and/or without amiodarone.
Takayuki Nagai; Kazuhiro Satomi; Takashi Noda; Hideo Okamura; Yuko Yamada; Wataru Shimizu; Kazuhiro Suyama; Naohiko Aihara; Shiro Kamakura; Takashi Kurita
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Publication Detail:
Type:  Journal Article     Date:  2010-05-18
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  74     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-10-19     Revised Date:  2011-02-18    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1302-7     Citation Subset:  IM    
Department of Cardiovascular Medicine, National Cardiovascular Center, Suita, Japan.
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MeSH Terms
Amiodarone / administration & dosage*
Atrial Fibrillation
Defibrillators, Implantable / adverse effects*
Heart Diseases / therapy
Middle Aged
Retrospective Studies
Risk Factors
Treatment Failure
Reg. No./Substance:
Comment In:
Circ J. 2010 Jul;74(7):1290-1   [PMID:  20558884 ]

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