| Relationship between oral amiodarone and inappropriate therapy from an implantable cardioverter defibrillator. | |
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MedLine Citation:
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PMID: 20484827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study evaluated the efficacy of amiodarone for avoiding inappropriate therapies by implantable cardioverter defibrillators (ICDs). METHODS AND RESULTS: A total of 232 patients with structural heart disease (58+/-13 years; 78% males) who underwent an initial ICD implantation were retrospectively investigated to compare baseline characteristics and event rates of inappropriate ICD therapy delivery between patients with oral amiodarone therapy (amiodarone group, n=116) and those without (non-amiodarone group, n=116). During a mean follow-up of 29+/-21 months, inappropriate therapies occurred less frequently in the amiodarone group than in the non-amiodarone group (12% vs 27%, P=0.0068). As a cause of inappropriate ICD therapy, only atrial fibrillation (AF) significantly differed between the groups (3% vs 12%, P=0.01). The results of multivariate logistic regression analysis showed that amiodarone therapy (odds ratio (OR) 0.38, 95% confidence interval (CI) 0.19-0.77, P=0.0073) and no history of spontaneous AF (OR 0.27, 95%CI 0.13-0.57, P=0.0007) were independent predictors of a lower risk of inappropriate ICD therapy. CONCLUSIONS: In the present group of ICD patients with structural heart disease, inappropriate therapy delivery occurred predominantly in those with spontaneous AF and/or without amiodarone. |
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Authors:
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Takayuki Nagai; Kazuhiro Satomi; Takashi Noda; Hideo Okamura; Yuko Yamada; Wataru Shimizu; Kazuhiro Suyama; Naohiko Aihara; Shiro Kamakura; Takashi Kurita |
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Publication Detail:
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Type: Journal Article Date: 2010-05-18 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-30 Completed Date: 2010-10-19 Revised Date: 2011-02-18 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1302-7 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, National Cardiovascular Center, Suita, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amiodarone / administration & dosage* Atrial Fibrillation Defibrillators, Implantable / adverse effects* Female Heart Diseases / therapy Humans Male Middle Aged Prognosis Retrospective Studies Risk Factors Treatment Failure |
| Chemical | |
Reg. No./Substance:
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1951-25-3/Amiodarone |
| Comments/Corrections | |
Comment In:
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Circ J. 2010 Jul;74(7):1290-1
[PMID:
20558884
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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