Document Detail

Relationship between mean corpuscular volume and cognitive performance in older adults.
MedLine Citation:
PMID:  23301873     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To examine the relationship between erythrocyte mean corpuscular volume (MCV) and cognitive performance over time.
DESIGN: Longitudinal.
SETTING: Sample from the Baltimore Longitudinal Study of Aging (BLSA).
PARTICIPANTS: Eight hundred twenty-seven participants from the BLSA (mean age 67, range 50-96).
MEASUREMENTS: Mean corpuscular volume and several other blood indices were measured, including hemoglobin, iron, ferritin, vitamin B12, folate, white blood cell count, albumin, and erythrocyte sedimentation rate. Cognitive performance was examined using neuropsychological measures of visual memory, verbal memory, language, attention, executive function, and global mental status.
RESULTS: High MCV levels were significantly associated with lower global mental status even after adjusting for potential confounders. High MCV levels were also significantly associated with high rates of decline on tasks of global mental status, long delay memory, and attention, even after adjusting for potential confounders.
CONCLUSION: The findings confirm a previous observation that larger erythrocytes in older adults are associated with poorer cognitive function. Anemia and inflammation do not appear to explain the relationship between MCV and cognition. Further research is needed to clarify the mechanisms behind this association.
Alyssa A Gamaldo; Luigi Ferrucci; Joseph Rifkind; Dan L Longo; Alan B Zonderman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Intramural     Date:  2013-01-10
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  61     ISSN:  1532-5415     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-03-07     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-9     Citation Subset:  IM    
Copyright Information:
© 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society.
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MeSH Terms
Aged, 80 and over
Aging / blood*
Cognition / physiology*
Cognition Disorders / blood*,  psychology
Erythrocyte Indices
Erythrocytes / metabolism*
Follow-Up Studies
Middle Aged
Neuropsychological Tests
Retrospective Studies
Grant Support
Comment In:
J Am Geriatr Soc. 2013 Jan;61(1):155-7   [PMID:  23311556 ]

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