Document Detail

The relationship between maternal and fetal vitamin D, insulin resistance, and fetal growth.
MedLine Citation:
PMID:  22968764     Owner:  NLM     Status:  MEDLINE    
Evidence for a role of vitamin D in maintaining normal glucose homeostasis is inconclusive. We sought to clarify the relationship between maternal and fetal insulin resistance and vitamin D status. This is a prospective cohort study of 60 caucasian pregnant women. Concentrations of 25-hydroxyvitamin D (25-OHD), glucose, insulin, and leptin were measured in early pregnancy and at 28 weeks. Ultrasound at 34 weeks assessed fetal anthropometry including abdominal wall width, a marker of fetal adiposity. At delivery birth weight was recorded and fetal 25-OHD, glucose, C-peptide, and leptin measured in cord blood. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA) equation. We found that those with lower 25-OHD in early pregnancy had higher HOMA indices at 28 weeks, (r = -.32, P = .02). No significant relationship existed between maternal or fetal leptin and 25-OHD, or between maternal or fetal 25-OHD and fetal anthropometry or birth weight. The incidence of vitamin D deficiency was high at each time point (15%-45%). These findings lend support to routine antenatal supplementation with vitamin D in at risk populations.
Jennifer M Walsh; Ciara A McGowan; Mark Kilbane; Malachi J McKenna; Fionnuala M McAuliffe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-11
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  20     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-24     Completed Date:  2013-11-25     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  536-41     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Blood Glucose / metabolism
Fetal Blood / metabolism*
Fetal Development
Fetal Macrosomia / blood,  etiology*,  physiopathology
Gestational Age
Insulin / blood
Insulin Resistance*
Leptin / blood
Longitudinal Studies
Prospective Studies
Risk Factors
Vitamin D / analogs & derivatives*,  blood
Vitamin D Deficiency / blood,  complications*,  physiopathology
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Insulin; 0/Leptin; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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