| The Relationship Between Maternal and Fetal Vitamin D, Insulin Resistance, and Fetal Growth. | |
| | |
MedLine Citation:
|
PMID: 22968764 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Evidence for a role of vitamin D in maintaining normal glucose homeostasis is inconclusive. We sought to clarify the relationship between maternal and fetal insulin resistance and vitamin D status. This is a prospective cohort study of 60 caucasian pregnant women. Concentrations of 25-hydroxyvitamin D (25-OHD), glucose, insulin, and leptin were measured in early pregnancy and at 28 weeks. Ultrasound at 34 weeks assessed fetal anthropometry including abdominal wall width, a marker of fetal adiposity. At delivery birth weight was recorded and fetal 25-OHD, glucose, C-peptide, and leptin measured in cord blood. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA) equation. We found that those with lower 25-OHD in early pregnancy had higher HOMA indices at 28 weeks, (r = -.32, P = .02). No significant relationship existed between maternal or fetal leptin and 25-OHD, or between maternal or fetal 25-OHD and fetal anthropometry or birth weight. The incidence of vitamin D deficiency was high at each time point (15%-45%). These findings lend support to routine antenatal supplementation with vitamin D in at risk populations. |
| | |
Authors:
|
Jennifer M Walsh; Ciara A McGowan; Mark Kilbane; Malachi J McKenna; Fionnuala M McAuliffe |
Related Documents
:
|
15554884 - Role of thyroid hormone during early brain development. 23268584 - A standard approach to continuous glucose monitor data in pregnancy for the study of fe... 2423874 - Antithyroid drug therapy for graves' disease during pregnancy. optimal regimen for feta... 11225824 - Progress in pulsed-current karl fischer coulometry using diaphragm-free cells. 11967184 - Ultrastructural characteristics of fresh and frozen-thawed ovine embryos using two cryo... 8416464 - Preterm delivery among black and white enlisted women in the united states army. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-11 |
Journal Detail:
|
Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: - ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Homoeology of Thinopyrum junceum and Elymus rectisetus chromosomes to wheat and disease resistance c...
Next Document: Thermally and photo-induced spin crossover behaviour in an Fe(ii) imidazolylimine complex: [FeL(3)](...