Document Detail

The Relationship Between Lipid Peroxidation and LDL Desialylation in Experimental Atherosclerosis.
MedLine Citation:
PMID:  20020949     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT High serum total cholesterol concentration has been strongly connected with atherosclerosis in numerous studies. Being the main carrier of cholesterol in blood, low-density lipoprotein (LDL) is also the principal lipoprotein causing atherosclerosis. Sialic acids are a family of amino sugars that are commonly found as terminal oligosaccharide residues on glycoproteins and are sialylated on their apolipoprotein and glycolipid constituents. In several studies, it was demonstrated that LDL has a 2.5- to 5-fold lower content of sialic acid in patients with coronary artery disease compared with healthy subjects. The role of oxidatively modified LDL in the pathogenesis has been well documented. These studies have focused on modifications in the lipid and protein parts of LDL. But recently, desialylated LDL and its relation with the oxidation mechanisms have received attention in the pathogenesis of atherosclerosis and coronary artery disease (CAD). From these points, we have performed atheroma plaques in an experimental atherosclerosis model with rabbits and examined the LDL and plasma sialic acid and thiobarbituric acid reactive substance (TBARS) levels in the same model. We also have determined serum sialidase enzyme activities relevant with these parameters. LDL sialic acid levels were significantly decreased in the progression of the atherosclerosis (by the 30th, 60th, and 90th days). LDL and plasma TBARS levels and plasma sialidase enzyme activities were significantly elevated by the same time periods. In conclusion, serum sialidase enzyme may play an important role in the desialylation mechanism, and reactive oxygen substance (ROS) may affect this reaction.
Zeynep Oztürk; Hüseyin Sönmez; F Murat Görgün; Hakan Ekmekçi; Dilek Bilgen; Naile Ozen; Volkan Sözer; Tuncay Altuğ; Emine Kökoğlu
Related Documents :
8633679 - Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in pre...
1445239 - Extracellular fatty acids are not utilized directly for the synthesis of very-low-densi...
15765889 - Lipaemia, inflammation and atherosclerosis: novel opportunities in the understanding an...
2930479 - Processing of cholesteryl ester from low-density lipoproteins in the rat. hepatic metab...
9026539 - Oxidized lipids in the diet are incorporated by the liver into very low density lipopro...
2169029 - Selective inhibition of the uptake by bloodstream form trypanosoma brucei brucei of ser...
15541339 - C75 activates malonyl-coa sensitive and insensitive components of the cpt system.
3522109 - Manganese: its acquisition by and function in the lactic acid bacteria.
1776279 - Are free radicals involved in lead poisoning?
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology mechanisms and methods     Volume:  17     ISSN:  1537-6524     ISO Abbreviation:  Toxicol. Mech. Methods     Publication Date:  2007  
Date Detail:
Created Date:  2009-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134521     Medline TA:  Toxicol Mech Methods     Country:  England    
Other Details:
Languages:  eng     Pagination:  265-73     Citation Subset:  -    
Department of Biochemistry, Cerrahpaşa School of Medicine, Istanbul University, Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The Toxicity of Soman in the African Green Monkey (Chlorocebus aethiops).
Next Document:  Role of vitamin b(6) deficiency in the nitrogen balance of streptozotocin-diabetic rats.