Document Detail


Relationship between intraocular pressure and angle configuration: an anterior segment OCT study.
MedLine Citation:
PMID:  23299476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To assess the relationship between intraocular pressure (IOP) and anterior chamber angle (ACA) configuration as assessed by gonioscopy and anterior segment optical coherence tomography (AS-OCT).
METHODS: A total of 2045 subjects aged 50 years and older, were recruited from a community clinic and underwent AS-OCT, Goldmann applanation tonometry, and gonioscopy. A quadrant was classified as closed on gonioscopy if the posterior trabecular meshwork could not be seen. A closed quadrant on AS-OCT was defined by the presence of any contact between the iris and angle wall anterior to the scleral spur. Customized software (Zhongshan Angle Assessment Program, Guangzhou, China) was used to measure AS-OCT parameters on AS-OCT scans, including anterior chamber depth, area, and volume; iris thickness (IT) and curvature; lens vault; angle opening distance; and trabecular-iris space area. IOP values were adjusted for age, sex, diabetes and hypertension status, body mass index, central corneal thickness, and presence of peripheral anterior synechiae.
RESULTS: Mean age of study subjects was 63.2 ± 8.0 years, 52.6% were female, and 89.4% were Chinese. Mean IOP was 14.8 ± 2.4 mm Hg (range 826). IOP (mean ± SE) increased with number of quadrants with gonioscopic angle closure (none: 14.6 ± 0.2; one: 14.7 ± 0.3; two: 15.0 ± 0.3; three: 15.0 ± 0.3; four: 15.6 ± 0.3 mm Hg; P < 0.001), and on AS-OCT (none: 14.7 ± 0.2; one: 15.0 ± 0.2; two: 14.8 ± 0.2; three: 15.1 ± 0.3; four: 16.0 ± 0.3 mm Hg; P < 0.001). IOP also increased in association with most of the ACA quantitative parameters measured on AS-OCT images, except for IT and lens vault.
CONCLUSIONS: There was an association between the extent of angle closure, as assessed on AS-OCT and gonioscopy, with increasing IOP.
Authors:
Rachel S Chong; Lisandro M Sakata; Arun K Narayanaswamy; Sue-Wei Ho; Mingguang He; Mani Baskaran; Tien Yin Wong; Shamira A Perera; Tin Aung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-03-05
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  54     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-06     Completed Date:  2013-05-24     Revised Date:  2013-08-08    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1650-5     Citation Subset:  IM    
Affiliation:
Singapore Eye Research Institute and Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore.
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MeSH Terms
Descriptor/Qualifier:
Anterior Eye Segment / pathology*
Cross-Sectional Studies
Female
Glaucoma, Angle-Closure / diagnosis*
Gonioscopy
Humans
Intraocular Pressure*
Iris / pathology
Male
Middle Aged
Multivariate Analysis
Prospective Studies
Singapore
Tomography, Optical Coherence
Tonometry, Ocular
Trabecular Meshwork / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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