Document Detail

Relationship between functional exercise capacity and functional stenosis in patients with stable angina and intermediate coronary stenosis.
MedLine Citation:
PMID:  19838006     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Some stable angina patients with significant coronary function have low exercise capacity, whereas some have high exercise capacity. The aim of the present study was to determine whether coronary pressure-derived fractional flow reserve (FFRmyo), a functional index of coronary stenosis, is a better indicator of exercise capacity than angiographic stenosis. METHODS AND RESULTS: The 15 male (65.8 +/-8.9 years old) subjects with stable angina and 75% angiographic stenosis underwent a cardiopulmonary exercise test (CPX), and peak oxygen uptake (PeakVO(2)) and oxygen uptake at anaerobic threshold (AT) were measured. The relationship between FFRmyo and CPX values was assessed. The left anterior descending artery was affected in 8 patients, the left circumflex artery in 5, and the right coronary artery in 2. Percent diameter stenosis (%DS) was 61.7 +/-9.1% by quantitative coronary angiography. Mean FFRmyo, PeakVO(2), and AT was 0.84 +/-0.66, 17.1 +/-3.2 ml x kg(-1) x min(-1), and 11.1 +/-2.0 ml x kg(-1) x min(-1), respectively. There was no significant correlation between %DS and FFRmyo, PeakVO(2), or AT (r=0.12, 0.051, and 0.013, respectively; P=NS), but FFRmyo had a significant positive correlation with PeakVO(2) and AT (r=0.534 and 0.542, respectively; P<0.05). CONCLUSIONS: Exercise capacity reflects functional stenosis in stable angina patients.
Shinichiro Tanaka; Toshiyuki Noda; Tomonori Segawa; Taro Minagawa; Sachiro Watanabe; Shinya Minatoguchi
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Publication Detail:
Type:  Journal Article     Date:  2009-10-17
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-26     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2308-14     Citation Subset:  IM    
Department of Cardiology, Gifu Prefectural General Medical Center, Gifu, Japan.
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MeSH Terms
Angina Pectoris / ethnology,  etiology*,  physiopathology,  radiography
Asian Continental Ancestry Group
Blood Pressure
Coronary Angiography*
Coronary Stenosis / complications,  ethnology,  physiopathology*,  radiography
Exercise Test*
Exercise Tolerance*
Fractional Flow Reserve, Myocardial*
Heart Catheterization
Japan / epidemiology
Middle Aged
Oxygen Consumption*
Predictive Value of Tests
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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