Document Detail

Relationship between body mass index and mortality in adults on maintenance hemodialysis: a systematic review.
MedLine Citation:
PMID:  20580250     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The primary objective of this systematic review was to determine the relationship between body mass index (BMI) and all-cause and cardiovascular mortality.
DESIGN: Systematic review of primarily observational studies.
PATIENTS: Adult patients from all gender, race, or ethnic groups on maintenance hemodialysis.
METHODS: Medline, Science Citation Index, Academic Search Premier, Cochrane Library, and Embase electronic databases covering the period 1966 to December 2008 were searched with the help of a qualified librarian. Reference lists of included papers and collections also were searched. Each study was reviewed by 2 independent reviewers who also performed the data extraction from full papers. Differences between reviewers were resolved by consensus or by a third reviewer in the case of disagreements. The quality of studies selected for inclusion in the systematic review was also assessed by 2 independent reviewers.
MAIN OUTCOMES: BMI and mortality.
RESULTS: Eighteen studies (60%) reported a significant inverse relationship between all-cause mortality and BMI. This inverse relationship was more prevalent in older patients, larger retrospective studies, and studies that did not adjust for inflammation. On the other hand, 57% of the 7 studies reporting on cardiovascular mortality found no significant relationship with BMI.
CONCLUSIONS: This systematic review shows evidence of an inverse relationship between BMI and all-cause mortality in adult patients on maintenance HD, especially in older patients, but the relationship with cardiovascular mortality is less clear.
Marietjie Herselman; Nazeema Esau; Jean-Marie Kruger; Demetre Labadarios; Mohammed Rafique Moosa
Publication Detail:
Type:  Journal Article; Review     Date:  2010-06-26
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  20     ISSN:  1532-8503     ISO Abbreviation:  J Ren Nutr     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  281-292, 7 p following 292     Citation Subset:  IM    
Copyright Information:
(c) 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
Division of Human Nutrition, Stellenbosch University, Tygerberg, South Africa.
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MeSH Terms
Age Distribution
Body Mass Index*
Cardiovascular Diseases / complications,  mortality*
Cause of Death
Kidney Failure, Chronic / complications,  mortality*,  therapy
Renal Dialysis*
Retrospective Studies
Severity of Illness Index

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