Document Detail


Relationship of angiotensin converting enzyme gene polymorphism and hypertension in Yogyakarta, Indonesia.
MedLine Citation:
PMID:  21063039     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
AIM: To evaluate the association between ACE gene polymorphism I/D and hypertension in Yogyakarta population.
METHODS: This study is a cross-sectional. Sample was taken by random sampling method from hypertensive, prehypertensve and normotensive subjects; from that were obtained 125 subjects, 97 subjects and 108 subjects, consecutively. ACE gene polymorphism I/D was examined by PCR. Genotype was classified as II, ID, or DD based on positive or negative insertion/delation allele.
RESULTS: This study shows significant differences of three groups (ages, body mass index (BMI), and family history of hypertension) and total cholesterol level in blood, which tends to have greater value in the hypertension group. Frequency of genotype II, ID, DD are 85 (68%), 39 (31.2%), 1 (0.8%) in hypertension, 66 (61.1%), 38 (35.2%), 4 (3.7%) in normo-tension and 56 (57.7%), 37 (38.1%), 4 (4.1%) in pre-hypertension subject, consecutively. Chi-square analysis shows statistically significant association between ID+DD vs. II genotype and hypertension. Multiple logistic regression analysis shows four variables that significantly influence to hypertension, namely ages, family history of hypertension, BMI, and ACE gene polymorphism.
CONCLUSION: ACE ID+DD genotype has significant relationship with hypertension in Melati population, Sleman, Yogyakarta, Indonesia.
Authors:
Lucky A Bawazier; Mochammad Sja'bani; Sofia M Haryana; Marsetyawan H N E Soesatyo; Ahmad H Sadewa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Indonesiana     Volume:  42     ISSN:  0125-9326     ISO Abbreviation:  Acta Med Indones     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7901042     Medline TA:  Acta Med Indones     Country:  Indonesia    
Other Details:
Languages:  eng     Pagination:  192-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Faculty of Medicine, University of Indonesia-dr. Cipto Mangunkusumo Hospital. Jl. Diponegoro no. 71, Jakarta Pusat 10430, Indonesia. lucky_aziza@cbn.net.id
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