| Relationship Among Diffuse Pulmonary Fibrosis, Alveolar Proteinosis And Anti-GM-CSF Autoantibodies. | |
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MedLine Citation:
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PMID: 21513605 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Extensive pulmonary fibrosis is a rare occurrence in pulmonary alveolar proteinosis (PAP). We herein report on two cases which have interesting implications; the first is a female patient diagnosed with autoimmune PAP, which evolved over seven years into diffuse fibrosis; the second is a male patient with diffuse fibrosis in which we incidentally detected electron microscopic features of alveolar surfactant accumulation and positive autoantibodies to anti GM-CSF. With regard to the former case, we speculated that the pulmonary fibrosis in this patient might have been preceded by an asymptomatic phase of autoimmune PAP, and that involvement of surfactant dysfunction in the pathogenesis of fibrotic lung disease should be addressed by future investigations. |
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Authors:
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Maurizio Luisetti; Pierdonato Bruno; Zamir Kadija; Takuji Suzuki; Salvatore Raffa; Maria Rosaria Torrisi; Ilaria Campo; Francesca Mariani; Ernesto Pozzi; Bruce C Trapnell; Salvatore Mariotta |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-19 |
Journal Detail:
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Title: Respiratory care Volume: - ISSN: 0020-1324 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7510357 Medline TA: Respir Care Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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