Document Detail

Relations of serum phosphorus levels to echocardiographic left ventricular mass and incidence of heart failure in the community.
MedLine Citation:
PMID:  20675668     Owner:  NLM     Status:  MEDLINE    
AIMS: To evaluate the association of serum phosphorus with cardiac structure/function and incident heart failure.
METHODS AND RESULTS: We related serum phosphorus to echocardiographic left ventricular (LV) measurements cross-sectionally, and to incident heart failure prospectively in 3300 participants (mean age 44 years, 51% women) free of heart failure, myocardial infarction, and chronic kidney disease (estimated glomerular filtration rate [eGFR]<60 mL/min/1.73 m(2)). Cross-sectionally, serum phosphorus was related positively to LV mass, internal dimensions, and systolic dysfunction. On follow-up (mean 17.4 years), 157 individuals developed heart failure. In models adjusting for established risk factors as time-varying covariates, each mg/dL increment in serum phosphorus was associated with a 1.74-fold risk of heart failure [95% confidence intervals (CI) 1.17-2.59]. Individuals in the highest serum phosphorus quartile experienced a two-fold (95% CI 1.28-3.40) risk of heart failure compared with participants in the lowest quartile. These relations were maintained upon additional adjustment for LV mass/dimensions and systolic dysfunction. In analyses restricted to individuals with eGFR >90 mL/min/1.73 m(2), no proteinuria and serum phosphorus <4.5 mg/dL, the association of serum phosphorus with heart failure remained robust.
CONCLUSION: In our community-based sample, higher serum phosphorus was associated with greater LV mass cross-sectionally, and with an increased risk of heart failure prospectively.
Ravi Dhingra; Philimon Gona; Emelia J Benjamin; Thomas J Wang; Jayashri Aragam; Ralph B D'Agostino; William B Kannel; Ramachandran S Vasan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  European journal of heart failure     Volume:  12     ISSN:  1879-0844     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2011-06-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  812-8     Citation Subset:  IM    
National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA, USA.
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MeSH Terms
Computer Simulation
Confidence Intervals
Cross-Sectional Studies
Disease Progression
Glomerular Filtration Rate
Heart Failure / epidemiology,  pathology,  ultrasonography*
Heart Ventricles / pathology,  ultrasonography*
Hypertrophy, Left Ventricular / epidemiology,  pathology,  ultrasonography*
Logistic Models
Multivariate Analysis
Phosphorus / blood*
Proportional Hazards Models
Prospective Studies
Residence Characteristics
Risk Assessment
Risk Factors
United States / epidemiology
Grant Support
Reg. No./Substance:

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