| Relations of central and brachial blood pressure to left ventricular hypertrophy and geometry: the Strong Heart Study. | |
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MedLine Citation:
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PMID: 20051906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We previously demonstrated stronger relations of central vs. brachial blood pressure, particularly pulse pressure, to carotid artery hypertrophy and extent of atherosclerosis. Data regarding the relative impacts of central and brachial pressures on left ventricular hypertrophy and geometry are limited. METHODS: Echocardiography and radial applanation tonometry were performed in American Indian participants in the 4th Strong Heart Study examination. Left ventricular mass was calculated using an anatomically validated formula and adjusted for height. Brachial blood pressure was measured according to a standardized protocol. Central pressures were derived using a generalized transfer function. RESULTS: Of 2585 participants in the analysis, 60% were women, 21% had diabetes and 33% were hypertensive; the mean age was 40 +/- 17 years. All blood pressure variables were significantly related to left ventricular absolute and relative wall thicknesses and left ventricular mass index (all P < 0.001), with considerable variation in correlation coefficients (r = 0.135-0.432). Central and brachial systolic pressures were uniformly more strongly related to left ventricular wall thicknesses, diastolic diameter and mass index than their respective pulse pressures (all P < 0.005 by z statistics). Left ventricular relative wall thickness and mass index were more strongly related to central than brachial pressures. CONCLUSION: Left ventricular hypertrophy is more strongly related to systolic pressure than to pulse pressure. Furthermore central pressures are more strongly related than brachial pressures to concentric left ventricular geometry. These data suggest that absolute (systolic) pressure is more important in stimulating left ventricular hypertrophy and remodeling, whereas pulsatile stress (pulse pressure) is more important in causing vascular hypertrophy and atherosclerosis. |
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Authors:
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Mary J Roman; Peter M Okin; Jorge R Kizer; Elisa T Lee; Barbara V Howard; Richard B Devereux |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-20 Completed Date: 2010-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 384-8 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Weill Cornell Medical College, New York 10021, USA. mroman@med.cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology* Brachial Artery Diabetes Complications / pathology, physiopathology, ultrasonography Echocardiography Female Humans Hypertension / complications, pathology*, physiopathology*, ultrasonography Hypertrophy, Left Ventricular / etiology, pathology*, physiopathology*, ultrasonography Indians, North American Longitudinal Studies Male Manometry Middle Aged Pulse Radial Artery United States Ventricular Remodeling Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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HL41642/HL/NHLBI NIH HHS; HL41652/HL/NHLBI NIH HHS; HL41654/HL/NHLBI NIH HHS; HL65521/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2010 Feb;28(2):237-9
[PMID:
20087105
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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