Document Detail


Relations between spontaneous and induced arterial lesions in swine and arteriosclerosis in humans.
MedLine Citation:
PMID:  598459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rabbit which for practical reasons is so frequently used for experimental arteriosclerosis considerably differs from humans in its metabolism, nourishment, and arterial wall responses to atherogenic noxae. In this respect, domestic pigs show more resemblance to the conditions in man, and they have recently been used for experimental research work in the field of atherosclerosis. Our own investigations performed with a view to constructing an antherosclerosis model being as far as possible resemblant to conditions prevailing in humans have shown that among various forms of diets only one combined form which is rich in cholesterol (1.5 percent) and lipids (15 percent) produces changes in the intima that in certain arterial regions correspond to lesions found in humans. These are lipofibrous beds up to complicated atheromas. The location of the spontaneous changes (without atherogenic diet) suggest that these may be considered as early stages. The various forms of development were studied light- and electron-microscopically; moreover the development of the blood lipids was determined biochemically during the experiment.
Authors:
J Massmann; H Müller; H Weidenbach; J Wagner; H Krug
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experimentelle Pathologie     Volume:  14     ISSN:  0014-4908     ISO Abbreviation:  Exp Pathol (Jena)     Publication Date:    1977 Jul-Aug
Date Detail:
Created Date:  1978-03-10     Completed Date:  1978-03-10     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0113124     Medline TA:  Exp Pathol (Jena)     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  89-99     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / pathology
Arteries / pathology*
Arteriosclerosis / etiology,  pathology*
Carotid Arteries / pathology
Coronary Vessels / pathology
Diet, Atherogenic
Disease Models, Animal*
Humans
Inflammation
Macrophages
Male
Muscle, Smooth / ultrastructure
Swine
Thoracic Arteries / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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