Document Detail

Relations between protein intake and blood pressure in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS).
MedLine Citation:
PMID:  19515740     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An inverse association between protein intake and blood pressure has been reported in Western countries. However, the evidence is limited for Asians, whose protein sources are different from those in Western populations.
OBJECTIVES: The objective was to examine the association between protein intake and blood pressure in Japanese adults.
METHODS: We conducted a population-based, cross-sectional study of 7585 subjects (3499 men and 4086 women) from 40 to 69 y of age living in 5 communities in Japan. Dietary intakes of total, animal, and plant protein were estimated by a single 24-h dietary recall. We then examined the associations between dietary intake of those proteins and blood pressure after adjustment for age, sex, community, body mass index, antihypertensive medication use, ethanol intake, smoking, and dietary intakes of sodium, potassium, and calcium.
RESULTS: After adjustment for cardiovascular disease risk factors, a 25.5-g/d increment in total protein intake was associated with a decrease in systolic blood pressure of 1.14 mm Hg (P < 0.001) and in diastolic blood pressure of 0.65 mm Hg (P < 0.001), and a 19.9-g/d increment in animal protein intake was associated with a decrease in systolic blood pressure of 1.09 mm Hg (P < 0.001) and in diastolic blood pressure of 0.41 mm Hg (P = 0.003). A 13.1-g/d increment in plant protein intake was associated with a decrease in diastolic blood pressure of 0.57 mm Hg (P < 0.001). Further adjustment for nutritional factors weakened these associations, but the inverse associations of total protein intake with diastolic blood pressure and of animal protein intake with systolic blood pressure remained statistically significant.
CONCLUSION: Total and animal protein intakes were inversely associated with blood pressure in Japanese adults.
Mitsumasa Umesawa; Shinichi Sato; Hironori Imano; Akihiko Kitamura; Takashi Shimamoto; Kazumasa Yamagishi; Takeshi Tanigawa; Hiroyasu Iso
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-10
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  90     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-08-03     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-84     Citation Subset:  AIM; IM    
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MeSH Terms
Age Distribution
Blood Pressure / drug effects*,  physiology*
Calcium, Dietary / administration & dosage
Cohort Studies
Cross-Sectional Studies
Dietary Proteins / administration & dosage*
Dose-Response Relationship, Drug
Health Surveys
Hypertension / epidemiology*,  etiology
Japan / epidemiology
Mental Recall
Middle Aged
Multivariate Analysis
Potassium, Dietary / administration & dosage
Sex Distribution
Sodium, Dietary / administration & dosage
Vegetable Proteins / administration & dosage
Reg. No./Substance:
0/Calcium, Dietary; 0/Dietary Proteins; 0/Potassium, Dietary; 0/Sodium, Dietary; 0/Vegetable Proteins

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