Document Detail

Relations between maternal and fetal plasma concentrations of placental lactogen and placental and fetal weights in well-fed ewes.
MedLine Citation:
PMID:  2061238     Owner:  NLM     Status:  MEDLINE    
The concentration of ovine placental lactogen (oPL) in maternal plasma varies with litter size and nutritional status, making it difficult to compare these concentrations across studies. In this study, 27 Dorset and Finn-Dorset crossbred ewes with litters of known size and gestational age were used to relate concentrations of oPL in maternal plasma to placental and fetal weights. Fetal oPL concentrations also were correlated to these variables in 12 chronically catheterized singleton fetuses. The concentration of oPL in maternal plasma increased with increasing placental weight across litter sizes ranging from 1 to 3 (r = .716). When expressed per gram of placenta, oPL was greater (P less than .05) in those ewes carrying multiple fetuses. There was no correlation between maternal and fetal oPL in time-matched samples or in average values between individuals for ewes carrying singleton pregnancies. Within the singleton group, placental weight and fetal weight were well correlated (r = .761), as were the concentration of fetal plasma oPL and fetal weight (r = .699). Placental weight plus fetal oPL could explain 81% of the variation seen in fetal weight. These results imply that maternal and fetal oPL release are controlled independently and that fetal oPL affects fetal growth by a mechanism not directly related to placental size.
P A Schoknecht; S N Nobrega; J A Petterson; R A Ehrhardt; R Slepetis; A W Bell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of animal science     Volume:  69     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-08-07     Completed Date:  1991-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1059-63     Citation Subset:  IM    
Department of Anim. Sci., Cornell University, Ithaca, NY 14853.
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MeSH Terms
Embryonic and Fetal Development*
Fetal Blood / chemistry
Gestational Age
Litter Size
Organ Size
Placenta / anatomy & histology*
Placental Lactogen / blood*
Pregnancy, Animal / blood,  metabolism*
Regression Analysis
Sheep / blood,  metabolism*
Reg. No./Substance:
9035-54-5/Placental Lactogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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