Document Detail

Relations between digital thermal monitoring of vascular function, the Framingham risk score, and coronary artery calcium score.
MedLine Citation:
PMID:  19083982     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Digital thermal monitoring (DTM) of vascular function was shown to correlate with the presence of known coronary artery disease (CAD). OBJECTIVE: We evaluated whether DTM can identify at-risk, asymptomatic patients with significant coronary artery calcium (CAC) or increased Framingham risk score (FRS). METHODS: Two hundred thirty-three consecutive asymptomatic subjects (58 +/- 11 years; 62% men) without known CAD underwent DTM, CAC, and FRS calculation. DTM measurements were obtained during and after a 5-minute suprasystolic arm-cuff occlusion. After cuff-deflation temperature rebound (TR) and area under the temperature curve (AUC) were measured and correlated with FRS and CAC. RESULTS: TR was lower in patients with FRS > 20% and CAC >or= 100 as compared with FRS < 10% and CAC < 10, respectively (P < 0.05). After adjustment for age, sex, and traditional cardiac risk factors, the odds ratio of the lowest compared with the upper 2 tertiles of TR was 3.96 for FRS >or= 20% and 2.37 for CAC >or= 100 compared with low-risk cohorts. The area under the receiver operating characteristic (ROC) curve to predict CAC >or= 100 increased significantly from 0.66 for FRS to 0.79 for TR to 0.89 for TR + FRS. CONCLUSIONS: Vascular dysfunction measured by DTM strongly correlates with FRS and CAC independent of age, sex, and traditional cardiac risk factors and was superior to FRS for the prediction of significant CAC.
Naser Ahmadi; Fereshteh Hajsadeghi; Khawar Gul; Jackson Vane; Nudrat Usman; Ferdinand Flores; Khurram Nasir; Harvey Hecht; Morteza Naghavi; Matthew Budoff
Publication Detail:
Type:  Case Reports; Comparative Study; Evaluation Studies; Journal Article     Date:  2008-09-26
Journal Detail:
Title:  Journal of cardiovascular computed tomography     Volume:  2     ISSN:  1876-861X     ISO Abbreviation:  -     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308347     Medline TA:  J Cardiovasc Comput Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  382-8     Citation Subset:  IM    
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, RB2, Torrance, CA 90502, USA.
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MeSH Terms
Calcinosis / diagnosis*,  epidemiology*
Coronary Artery Disease / diagnosis*,  epidemiology*
Diagnosis, Computer-Assisted / methods
Middle Aged
Reproducibility of Results
Risk Assessment / methods*
Risk Factors
Sensitivity and Specificity
Signal Processing, Computer-Assisted
Statistics as Topic
Thermography / methods*
United States / epidemiology
Comment In:
J Cardiovasc Comput Tomogr. 2008 Nov;2(6):389-91   [PMID:  19083983 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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