| Relations between carotid artery distensibility and heart rate variability The Cardiovascular Risk in Young Finns Study. | |
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MedLine Citation:
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PMID: 21292566 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Reduction in carotid artery wall elasticity may interfere with baroreceptor function that could lead to low vagal tone. We studied at the population level the relations between carotid-artery-distensibility (Cdist) and vagal modulation of heart rate. METHODS AND RESULTS: Cdist was assessed with ultrasonic measurements of changes in carotid artery diameter during cardiac-cycle. Vagal tone was estimated with the heart rate variability (HRV) in 1872 healthy 24-39year-old subjects. Cdist was significantly related with all HRV-components (always P<0.0001). After adjustments with sex, age and heart rate, we found statistically significant correlation between Cdist and the high-frequency component (HF, estimate of vagal-tone) of HRV (P<0.05). An inverse association between the number of cardiovascular risk-factors and vagal-tone was seen in subjects with less elastic arteries, but not in subjects with more elastic arteries (P for interaction=0.01). CONCLUSIONS: These data support the hypothesis that reduction in carotid artery wall elastic properties may lead to low vagal tone. Furthermore, carotid distensibility seemed to modify the relation between risk-factors and HRV. Increased cardiovascular risk associated with low vagal tone may partly be mediated via changes in carotid artery elastic properties. |
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Authors:
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Tuomas Koskinen; Markus Juonala; Mika Kähönen; Antti Jula; Tomi Laitinen; Liisa Keltikangas-Järvinen; Jorma Viikari; Ilkka Välimäki; Olli T Raitakari |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-1 |
Journal Detail:
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Title: Autonomic neuroscience : basic & clinical Volume: - ISSN: 1872-7484 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100909359 Medline TA: Auton Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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