Document Detail


Relations between carotid artery distensibility and heart rate variability The Cardiovascular Risk in Young Finns Study.
MedLine Citation:
PMID:  21292566     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Reduction in carotid artery wall elasticity may interfere with baroreceptor function that could lead to low vagal tone. We studied at the population level the relations between carotid-artery-distensibility (Cdist) and vagal modulation of heart rate. METHODS AND RESULTS: Cdist was assessed with ultrasonic measurements of changes in carotid artery diameter during cardiac-cycle. Vagal tone was estimated with the heart rate variability (HRV) in 1872 healthy 24-39year-old subjects. Cdist was significantly related with all HRV-components (always P<0.0001). After adjustments with sex, age and heart rate, we found statistically significant correlation between Cdist and the high-frequency component (HF, estimate of vagal-tone) of HRV (P<0.05). An inverse association between the number of cardiovascular risk-factors and vagal-tone was seen in subjects with less elastic arteries, but not in subjects with more elastic arteries (P for interaction=0.01). CONCLUSIONS: These data support the hypothesis that reduction in carotid artery wall elastic properties may lead to low vagal tone. Furthermore, carotid distensibility seemed to modify the relation between risk-factors and HRV. Increased cardiovascular risk associated with low vagal tone may partly be mediated via changes in carotid artery elastic properties.
Authors:
Tuomas Koskinen; Markus Juonala; Mika Kähönen; Antti Jula; Tomi Laitinen; Liisa Keltikangas-Järvinen; Jorma Viikari; Ilkka Välimäki; Olli T Raitakari
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-1
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  -     ISSN:  1872-7484     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.
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