Document Detail

Relations of adiposity and effects of training on the left ventricle in obese youths.
MedLine Citation:
PMID:  12218734     Owner:  NLM     Status:  MEDLINE    
PURPOSE: 1) To determine the relations of left ventricular (LV) structure and function to total body composition, visceral adipose tissue (VAT), and hemodynamics in obese children; 2) to determine the effects of 4-month of physical training (PT) on LV structure and function and hemodynamics; and 3) to explore determinants of individual variability in response to PT. METHODS: Measurements included LV structure/function with echocardiography, total body composition with dual-energy x-ray absorptiometry, VAT with magnetic resonance imaging (MRI), and resting and exercising hemodynamics with a Dinamap monitor and Doppler-echocardiography. Youths were randomly assigned to engage in PT for the first or second 4-month periods of the 8-month intervention period. RESULTS: Correlation and regression at baseline showed that elevated LV mass was associated with excess general and visceral adiposity, and elevated cardiac output. Although the PT had favorable effects on percent body fat and VAT, no significant changes were found in LV or hemodynamic variables. Over the 4-month period of the PT intervention, those who increased the most in VAT tended to increase the most in LV mass. CONCLUSION: General and visceral adiposity were associated with elevated LV mass. However, no evidence was provided that 4 months of PT had a significant effect on LV or hemodynamic variables.
Matthew C Humphries; Bernard Gutin; Paule Barbeau; Sarita Vemulapalli; Jerry Allison; Scott Owens
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  34     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-09     Completed Date:  2002-12-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1428-35     Citation Subset:  IM; S    
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, 1499 Walton Way, HS1640, Augusta, GA 30912, USA.
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MeSH Terms
Adipose Tissue / anatomy & histology
Analysis of Variance
Body Constitution / physiology
Echocardiography, Doppler
Exercise Therapy / methods*
Health Education / methods
Heart Ventricles / anatomy & histology*
Magnetic Resonance Imaging
Obesity / therapy*
Physical Fitness / physiology
Regression Analysis
Ventricular Function
Ventricular Function, Left / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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