Document Detail


Relations of circulating resistin and adiponectin and cardiac structure and function: the Framingham Offspring Study.
MedLine Citation:
PMID:  21350435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity is associated with pathological cardiac remodeling and risk of heart failure (HF). Adipocytokines (ADKs) may mediate the increased risk of cardiovascular disease associated with excess adiposity. Yet data relating ADKs to cardiac remodeling phenotypes are sparse. We related two circulating ADKs, resistin and adiponectin, to three important echocardiographic markers of cardiac remodeling, left ventricular mass (LVM), left atrial diameter (LAD), and LV fractional shortening (LVFS) in 2,615 participants (mean age 61 years, 55% women) in the Framingham Offspring Study. Adiponectin concentrations were inversely related to LVM in multivariable linear regression models adjusting for key clinical correlates including BMI (regression coefficient per s.d.-increment in ln-adiponectin = -3.37, P = 0.02; P for trend across quartiles = 0.02). Adiponectin was not associated with LAD or LVFS (P > 0.56). Resistin concentrations were inversely related to LVFS (regression coefficient per s.d.-increment in ln-resistin = -0.01, P = 0.03; P for trend across quartiles = 0.04). Resistin was not associated with LVM or LAD (P > 0.05). In our moderate-sized, community-based sample, higher circulating concentrations of adiponectin and resistin were associated with lower LVM and lower LVFS, respectively. In conclusion, these associations identify potential mechanisms by which excess adiposity may mediate adverse cardiac remodeling and HF risk.
Authors:
David D McManus; Asya Lyass; Erik Ingelsson; Joseph M Massaro; James B Meigs; Jayashri Aragam; Emelia J Benjamin; Ramachandran S Vasan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-02-24
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  20     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2013-01-02     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1882-6     Citation Subset:  IM    
Affiliation:
National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood*
Atrial Function, Left / physiology*
Biological Markers / blood
Cardiac Output
Community Health Services
Echocardiography
Female
Heart Function Tests
Humans
Insulin Resistance
Linear Models
Male
Middle Aged
Obesity / epidemiology*,  physiopathology
Pedigree
Resistin / blood*
Risk Factors
Ventricular Function, Left / physiology*
Ventricular Remodeling / physiology*
Grant Support
ID/Acronym/Agency:
2K24 HL04334/HL/NHLBI NIH HHS; 6R01-NS 17950/NS/NINDS NIH HHS; K24 HL004334/HL/NHLBI NIH HHS; N01 HC025195/HC/NHLBI NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; R01 DK080739/DK/NIDDK NIH HHS; R01 HL080124/HL/NHLBI NIH HHS; R01 NS017950/NS/NINDS NIH HHS; R01DK80739/DK/NIDDK NIH HHS; R01HL080124/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers; 0/Resistin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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