Document Detail

Relation of vitamin A and carotenoid status to growth failure and mortality among Ugandan infants with human immunodeficiency virus.
MedLine Citation:
PMID:  11448574     Owner:  NLM     Status:  MEDLINE    
Although growth failure is common during pediatric infection with human immunodeficiency virus (HIV) and associated with increased mortality, the relation of specific nutrition factors with growth and mortality has not been well characterized. A longitudinal study was conducted with 194 HIV-infected infants in Kampala, Uganda. Plasma vitamin A, carotenoids (alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, and lutein/zeaxanthin), and vitamin E were measured at age 14 wk, and weight and height were followed up to age 12 mo. Vitamin A and low plasma carotenoid concentrations were predictive of decreased weight and height velocity. Between ages 14 wk and 12 mo, 32% of infants died. Underweight, stunting, and low concentrations of plasma carotenoids were associated with increased risk of death in univariate analyses. Plasma vitamin A concentrations were not associated with risk of death. In a final multivariate model adjusting for weight-for-age, plasma beta-carotene was significantly associated with increased mortality (odds ratio: 3.16, 95% confidence interval: 1.38 to 7.21, P < 0.006). These data suggest that low concentrations of plasma carotenoids are associated with increased risk of death during HIV infection among infants in Uganda.
G Melikian; F Mmiro; C Ndugwa; R Perry; J B Jackson; E Garrett; J Tielsch; R D Semba
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  17     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    2001 Jul-Aug
Date Detail:
Created Date:  2001-07-12     Completed Date:  2002-01-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  567-72     Citation Subset:  IM    
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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MeSH Terms
Body Height
Body Weight
Carotenoids / blood*
Failure to Thrive / blood*,  mortality,  virology
HIV Infections / blood*,  complications,  mortality
Longitudinal Studies
Nutritional Status
Odds Ratio
Risk Factors
Vitamin A / blood*
Vitamin E / blood*
Grant Support
Reg. No./Substance:
11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 36-88-4/Carotenoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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