| Relation of ventricular-vascular coupling to exercise capacity in ischemic cardiomyopathy: a cardiac multi-modality imaging study. | |
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MedLine Citation:
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PMID: 19823943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to examine the relationship between noninvasive measurements of ventricular-vascular coupling (VVC) with exercise tolerance, and compared the value of VVC versus other traditional determinants of exercise capacity in this population. 43 patients with ischemic CMP (age 59 +/- 9 years, mean EF 24 +/- 8%) underwent cardiopulmonary exercise testing, echocardiography and cardiac magnetic resonance (CMR). VVC was defined non-invasively by the ratio of ventricular systolic elastance (Ees) to the arterial elastance (Ea), where Ees = end-systolic pressure/end-systolic volume index and Ea = end-systolic pressure/stroke volume index. VVC significantly correlated with baseline heart rate (HR), peak exercise systolic blood pressure, maximum oxygen consumption (MVO(2)) and peak O(2) pulse (MVO(2)/HR). A higher VVC was associated with higher LVEF and RVEF but showed inverse relation to mitral E wave velocity. Univariate predictors of MVO(2) are baseline HR, chronotropic reserve, VVC and aortic distensibility; whilst mitral E wave velocity, LVEF, VVC, Ees significantly correlated with peak O(2) pulse. By stepwise multivariate analysis, VVC remained the only independent predictor of peak O(2) pulse. Ventricular-vascular coupling at rest may be a clinically important parameter in predicting exercise capacity in patients with advanced heart failure, and may become an additional target for therapeutic interventions. |
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Authors:
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Raymond C Wong; Carlos A Dumont; Bethany A Austin; Deborah H Kwon; Scott D Flamm; James D Thomas; Randall C Starling; Milind Y Desai |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-10-13 |
Journal Detail:
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Title: The international journal of cardiovascular imaging Volume: 26 ISSN: 1875-8312 ISO Abbreviation: Int J Cardiovasc Imaging Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-08 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100969716 Medline TA: Int J Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 151-9 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine/F15, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA, rwongcc@gmail.com. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aorta / physiopathology* Cardiomyopathies / diagnosis, etiology, physiopathology*, surgery Echocardiography, Doppler, Color Echocardiography, Doppler, Pulsed Elasticity Exercise Test Exercise Tolerance* Female Heart Failure / diagnosis, etiology, physiopathology*, surgery Heart Rate Heart Transplantation Humans Magnetic Resonance Imaging Male Middle Aged Myocardial Ischemia / complications, diagnosis, physiopathology*, surgery Observer Variation Oxygen Consumption Predictive Value of Tests Reproducibility of Results Stroke Volume Ventricular Function, Left* Ventricular Function, Right Ventricular Pressure |
| Comments/Corrections | |
Comment In:
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Int J Cardiovasc Imaging. 2010 Feb;26(2):161-4
[PMID:
19937127
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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