| Relation of thickening of colon wall to pancreatic-enzyme treatment in cystic fibrosis. | |
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MedLine Citation:
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PMID: 7534369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibrotic strictures of the colon in association with colon-wall thickening on abdominal ultrasound have been described in children with cystic fibrosis. We determined the prevalence of colon-wall thickening in 99 children with cystic fibrosis (aged 6 months to 17 years, 45 male) and 38 healthy controls (aged 1 month to 39 years, 21 male). In controls, peristalsis was uniformly rapid and maximum wall thickness of the fully relaxed colon was 0.8 mm (median 0.6 mm). 24% of the patients had a colon-wall thickness of 1.5 mm or more (maximum 3.4 mm); 48% of children on high-strength pancreatin receiving more than 265 units/kg per day of protease had thickening of more than 1.5 mm compared with less than 12% of children on any other dose. Children on high-strength pancreatin were 5.2 (95% CI 1.2-21) times more likely to have colon-wall thickness of 1.5 mm or more than children taking less than 265 units/kg per day of protease in a standard-strength preparation. This risk rose to 10 (2.5-39) times more likely if laxatives were taken with a high-strength preparation. Lipase or amylase intake, age, sex, genotype, and other medical or drug history were not significantly associated with colon-wall thickening. 1 child required a hemicolectomy for bowel obstruction and another developed haemorrhagic colitis. In 17 children, 2 months after stopping high-strength, high protease, preparations and efforts to reduce enzyme intake, colon-wall thickness had regressed from a median 2.0 mm (range 1.0-3.4) to 1.8 mm (0.9-2.7) (p = 0.005). The use of high-strength pancreatin preparations in conjunction with a high protease intake probably causes thickening of the wall of the colon. |
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Authors:
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E J Mac Sweeney; P J Oades; R Buchdahl; M Rosenthal; A Bush |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lancet Volume: 345 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-04-14 Completed Date: 1995-04-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 752-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amylases / administration & dosage, therapeutic use* Child Child, Preschool Colon / drug effects, pathology*, ultrasonography Cystic Fibrosis / drug therapy*, pathology, ultrasonography Endopeptidases / administration & dosage, therapeutic use* Fibrosis Humans Infant Infant, Newborn Lipase / administration & dosage, therapeutic use* Logistic Models Male Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases; EC 3.4.-/Endopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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