| Relation of smoking and alcohol consumption to serum fatty acids. | |
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MedLine Citation:
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PMID: 8712189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the relation of cigarette smoking and alcohol consumption to serum fatty acid levels, the authors conducted a cross-sectional study of 190 men who were enrolled in the Multiple Risk Factor Intervention Trial between 1973 and 1976. After controlling for dietary fat, cholesterol, energy intake, and other potential confounders, the authors found that smoking and alcohol intake were associated with the serum cholesterol ester and phospholipid levels of several fatty acids. As the number of cigarettes smoked per day increased, the levels of cholesterol ester and phospholipid palmitoleic acid (16:1) and oleic acid (18:1) and the levels of phospholipid dihomogammalinolenic acid (20:3) and omega-9 eicosatrienoic acid (20:3) increased (all p's < or = 0.01). Serum levels of phospholipid omega-3 docosahexaenoic acid (22:6) and cholesterol ester and phospholipid arachidonic acid (20:4) were inversely associated with smoking (all p's < or = 0.01). As the number of alcoholic drinks per week increased, levels of cholesterol ester and phospholipid palmitic acid (16:0) and oleic acid (18:1), cholesterol ester myristic acid (14:0), and phospholipid palmitoleic acid (16:1), adrenic acid (22:4), and omega-9 eicosatrienoic acid (20:3) increased (all p's < 0.05), whereas levels of cholesterol ester and phospholipid linoleic acid (18:2) and phospholipid stearic acid (18:0) and the serum polyunsaturated fat: saturated fat ratio decreased (all p's < or = 0.01). These results suggest that smoking and alcohol consumption may influence the absorption, synthesis, or metabolism of serum fatty acids. Studies that use serum fatty acid levels as indicators of dietary fat intake should control for the effects of cigarette smoking and alcohol consumption. |
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Authors:
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J A Simon; J Fong; J T Bernert; W S Browner |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of epidemiology Volume: 144 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1996-09-10 Completed Date: 1996-09-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 325-34 Citation Subset: IM |
Affiliation:
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General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcohol Drinking / blood* Cerebrovascular Disorders / etiology Confounding Factors (Epidemiology) Coronary Disease / etiology Cross-Sectional Studies Fatty Acids / blood*, metabolism Humans Intestinal Absorption Male Middle Aged Multivariate Analysis Predictive Value of Tests Risk Factors Smoking / blood* |
| Grant Support | |
ID/Acronym/Agency:
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HL 32338/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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