Document Detail


Relation of size of secondary ventricles to exercise performance in children after fontan operation.
MedLine Citation:
PMID:  21094369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of the nondominant or secondary ventricle on the Fontan circulation are not known. The present study used cardiac magnetic resonance imaging to investigate the relations between secondary ventricular size and global cardiac performance. The Fontan cross-sectional study collected data from 7 centers participating in the Pediatric Heart Network. Subjects with complete cardiac magnetic resonance imaging data and an identifiable secondary ventricle were included in the analysis. Relationships between body surface area-adjusted parameters of the secondary ventricle (mass, end-diastolic volume, mass/volume ratio, and stroke volume) and the following measures were assessed. These measures included the percentage of predicted peak oxygen consumption and oxygen consumption at the ventilatory anaerobic threshold, ejection fraction of the main ventricular chamber, echocardiographic diastolic function grade, serum B-type natriuretic peptide, primary ventricular end-diastolic pressure, and parent-reported physical functioning summary score on the Child Health Questionnaire. Of the 546 enrolled subjects, 123 (age 12.1 ± 3.3 years, 56% male) had undergone cardiac magnetic resonance imaging, and 38 had achieved maximal aerobic capacity. A larger secondary ventricular end-diastolic volume, lower mass/volume ratio, and greater secondary/total ventricular stroke volume ratio were associated with a greater exercise capacity. No significant relationships were found between the measures of the secondary ventricle and the other outcomes. In conclusion, in children after the Fontan operation, a larger and less hypertrophied secondary ventricle with a greater contribution to stroke volume was associated with a better exercise capacity.
Authors:
Ashwin Prakash; Thomas G Travison; Mark A Fogel; Lynne M Hurwitz; Andrew J Powell; Beth F Printz; Michael D Puchalski; Girish S Shirali; Shi-Joon Yoo; Tal Geva;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of cardiology     Volume:  106     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-01-20     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1652-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Cross-Sectional Studies
Exercise Test
Exercise Tolerance / physiology*
Female
Follow-Up Studies
Fontan Procedure*
Heart Defects, Congenital / surgery*
Heart Ventricles / pathology*,  physiopathology
Humans
Magnetic Resonance Imaging / methods*
Male
Oxygen Consumption
Postoperative Period
Prospective Studies
Stroke Volume / physiology*
Treatment Outcome
Ventricular Function, Left / physiology*
Grant Support
ID/Acronym/Agency:
U01 HL068269/HL/NHLBI NIH HHS; U01 HL068270/HL/NHLBI NIH HHS; U01 HL068279/HL/NHLBI NIH HHS; U01 HL068281/HL/NHLBI NIH HHS; U01 HL068285/HL/NHLBI NIH HHS; U01 HL068285/HL/NHLBI NIH HHS; U01 HL068285-01/HL/NHLBI NIH HHS; U01 HL068285-10/HL/NHLBI NIH HHS; U01 HL068288/HL/NHLBI NIH HHS; U01 HL068290/HL/NHLBI NIH HHS; U01 HL068290/HL/NHLBI NIH HHS; U01 HL068290-06/HL/NHLBI NIH HHS; U01 HL068292/HL/NHLBI NIH HHS
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