| Relation of proximal aorta stiffness to left ventricular diastolic function in patients with end-stage renal disease. | |
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MedLine Citation:
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PMID: 17336760 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: We examined the relationship between proximal aortic stiffness and left ventricular (LV) diastolic function in patients with end-stage renal disease (ESRD). PATIENTS AND METHODS: We studied 99 patients with ESRD with preserved LV ejection fraction greater than 50% and 83 controls. We assessed the aorta stiffness by measuring the pulse wave velocity (PWV) in the proximal aorta (PWVr) using a novel echo application and in the descending aorta (PWVcf) using a foot-to-foot method. Patients were classified according to LV diastolic filling pattern into normal, delayed relaxation, pseudonormal, and restrictive filing pattern groups. RESULTS: Patients with ESRD had increased PWVr, PWVcf, and LV mass index (LVMI) compared with controls (all P < .0001). Patients with advanced diastolic dysfunction showed increased PWVr (P < .001) and PWVcf (P = .007) compared with those with mild diastolic dysfunction. PWVr was correlated to PWVcf (r = 0.74, P < .001) in patients with ESRD. Multivariate linear regression analysis revealed that PWVr was independently correlated to both LVMI and LV diastolic filling pattern. CONCLUSIONS: Increased LVMI, advanced LV diastolic dysfunction, and generalized aortic stiffening were observed in patients with ESRD. Proximal aorta stiffness is associated with both increased LVMI and advanced LV diastolic dysfunction in those patients. |
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Authors:
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Alexandros P Patrianakos; Fragiskos I Parthenakis; Dimitrios Karakitsos; Eric De Groot; Emmanuell A Skalidis; Eva Nyktari; Eugene Daphnis; Panos E Vardas |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 20 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-05 Completed Date: 2007-04-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 314-23 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University Hospital of Heraklion, Crete, Greece. patrianakos@edu.med.uoc.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aorta
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physiopathology*,
ultrasonography* Aortic Diseases / etiology, physiopathology*, ultrasonography* Cohort Studies Diastole* Elasticity Female Humans Image Interpretation, Computer-Assisted / methods Kidney Failure, Chronic / complications, physiopathology, ultrasonography* Male Middle Aged Statistics as Topic Ventricular Dysfunction, Left / etiology, physiopathology, ultrasonography* |
| Comments/Corrections | |
Comment In:
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J Am Soc Echocardiogr. 2007 Oct;20(10):1223
[PMID:
17681727
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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