| Relation of the prognostic value of ventilatory efficiency to body mass index in patients with heart failure. | |
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MedLine Citation:
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PMID: 18237598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ventilatory efficiency, minute ventilation (VE)/carbon dioxide production (VCO2), slope consistently provides valuable prognostic information in patients with heart failure (HF). Patients with a higher body mass index (BMI) have demonstrated an improved prognosis in the HF population, a phenomenon that has been termed the "obesity paradox." The purpose of this study was to evaluate the prognostic ability of the VE/VCO2 slope according to BMI in patients with HF. Seven-hundred four patients with HF (555 men, 149 women, mean age 56.8+/-13.4 years, ejection fraction 33.1+/-13.3%) with a BMI>or=18.5 kg/m2 underwent cardiopulmonary exercise testing. Subjects were divided into 3 BMI subgroups (18.5 to 24.9, 25.0 to 29.9, and >or=30 kg/m2). Each subject was tracked for major cardiac events (death, transplantation, left ventricular assist device implantation) for 2 years after testing. There were 86 major cardiac events (71 deaths, 10 transplantations, 5 left ventricular assist device implantations) during the 2-year tracking period (overall annual event rate 8.2%). The VE/VCO2 slope was the strongest prognostic marker in each BMI subgroup. Subjects in the highest BMI group had the lowest mean VE/VCO2 slope and the lowest rate of major cardiac events of the 3 groups. Multivariate Cox regression analysis showed that peak VO2 did not add additional prognostic value to the VE/VCO2 slope and was removed from the regression for each BMI subgroup. In conclusion, the findings of the present study indicate that VE/VCO2 slope maintains prognostic value irrespective of BMI in patients with HF. |
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Authors:
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Paul Chase; Ross Arena; Jonathan Myers; Joshua Abella; Mary Ann Peberdy; Marco Guazzi; Daniel Bensimhon |
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Publication Detail:
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Type: Journal Article Date: 2007-12-21 |
Journal Detail:
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Title: The American journal of cardiology Volume: 101 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-01 Completed Date: 2008-03-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 348-52 Citation Subset: AIM; IM |
Affiliation:
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LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA. paul.chase@mosescone.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Body Mass Index* Carbon Dioxide / metabolism Comorbidity Exercise Test Female Heart Failure / epidemiology, physiopathology* Humans Male Middle Aged Obesity / epidemiology, physiopathology Oxygen Consumption / physiology Prognosis Pulmonary Ventilation / physiology* ROC Curve Regression Analysis Stroke Volume |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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